cell-mediated immunity

cell-·me·di·at·ed im·mu·ni·ty (CMI),

, cellular immunityImmune responses mediated by activated, antigen-specific T lymphocytes. These T cells may function as effector cells or may orchestrate propagation of the inflammatory response and cellular recruitment through their secretion of cytokines and chemokines. Synonym(s): delayed hypersensitivity (1)

cell-mediated immunity

n. Immunity resulting from a cell-mediated immune response. Also called cellular immunity.

cell-me·di·at·ed im·mu·ni·ty

, cellular immunity (CMI) (sel'mē'dē-āt-ĕd i-myū'ni-tē, sel'yū-lăr) Immune responses that are initiated by T lymphocytes and mediated by T lymphocytes, macrophages, or both (e.g., graft rejection, delayed-type hypersensitivity).

CELL-MEDIATED IMMUNITY

cell-mediated immunity

Abbreviation: CMI.
The regulatory and cytotoxic activities of T cells during the specific immune response. This process requires about 36 hr to reach its full effect. Synonym: T-cell–mediated immunity See: illustration; humoral immunity

Unlike B cells, T cells cannot recognize foreign antigens on their own. Foreign antigens are recognized by antigen-presenting cells (APCs) such as macrophages, which engulf them and display part of the antigens on the APC's surface next to a histocompatibility or “self-” antigen (macrophage processing). The presence of these two markers, plus the cytokine interleukin-1 (IL-1) secreted by the APCs activates CD4 helper T cells (T_H cells), which regulate the activities of other cells involved in the immune response.

CMI includes direct lysis of target cells by cytotoxic T cells, creation of memory cells that trigger a rapid response when a foreign antigen is encountered for the second time, and delayed hypersensitivity to tissue and organ transplants. T cells also stimulate the activity of macrophages, B cells, and natural killer cells. These functions are controlled largely by the secretion of lymphokines such as the interleukins, interferons, and colony-stimulating factors. Lymphokines facilitate communication and proliferation of the cells in the immune system.

cell-mediated immunity

Action by the immune system involving T cells (T LYMPHOCYTES) and concerned with protection against viruses, fungi, TUBERCULOSIS and cancers and rejection of foreign grafted material. Cell-mediated immunity is not primarily effected by ANTIBODIES.

单词	cell-mediated immunity
释义	cell-mediated immunity cell-mediated immunity n. Immunity involving cells, such as T cells and phagocytes, in contrast with humoral immunity, which involves soluble proteins (antibodies). Also called cellular immunity. cell′-me`diated immu′nity n. immunity conferred to an individual through the activity of T cells, involving the direct destruction of viruses, foreign particles, etc. Compare antibody-mediated immunity. [1970–75] cell-mediated immunity cell-mediated immunity [¦sel ¦mē·dē‚ād·əd i′myü·nəd·ē] (immunology) Immune responses produced by the activities of T cells rather than by immunoglobulins. cell-mediated immunity cell-·me·di·at·ed im·mu·ni·ty (CMI), , cellular immunityImmune responses mediated by activated, antigen-specific T lymphocytes. These T cells may function as effector cells or may orchestrate propagation of the inflammatory response and cellular recruitment through their secretion of cytokines and chemokines. Synonym(s): delayed hypersensitivity (1) cell-mediated immunity n. Immunity resulting from a cell-mediated immune response. Also called cellular immunity. cell-me·di·at·ed im·mu·ni·ty , cellular immunity (CMI) (sel'mē'dē-āt-ĕd i-myū'ni-tē, sel'yū-lăr) Immune responses that are initiated by T lymphocytes and mediated by T lymphocytes, macrophages, or both (e.g., graft rejection, delayed-type hypersensitivity). CELL-MEDIATED IMMUNITY cell-mediated immunity Abbreviation: CMI. The regulatory and cytotoxic activities of T cells during the specific immune response. This process requires about 36 hr to reach its full effect. Synonym: T-cell–mediated immunity See: illustration; humoral immunity Unlike B cells, T cells cannot recognize foreign antigens on their own. Foreign antigens are recognized by antigen-presenting cells (APCs) such as macrophages, which engulf them and display part of the antigens on the APC's surface next to a histocompatibility or “self-” antigen (macrophage processing). The presence of these two markers, plus the cytokine interleukin-1 (IL-1) secreted by the APCs activates CD4 helper T cells (T_H cells), which regulate the activities of other cells involved in the immune response. CMI includes direct lysis of target cells by cytotoxic T cells, creation of memory cells that trigger a rapid response when a foreign antigen is encountered for the second time, and delayed hypersensitivity to tissue and organ transplants. T cells also stimulate the activity of macrophages, B cells, and natural killer cells. These functions are controlled largely by the secretion of lymphokines such as the interleukins, interferons, and colony-stimulating factors. Lymphokines facilitate communication and proliferation of the cells in the immune system. See also: immunity cell-mediated immunity Action by the immune system involving T cells (T LYMPHOCYTES) and concerned with protection against viruses, fungi, TUBERCULOSIS and cancers and rejection of foreign grafted material. Cell-mediated immunity is not primarily effected by ANTIBODIES. LegalSeeimmunitySee CMI See CMI
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cell-mediated immunity

cell-mediated immunity

cell′-me`diated immu′nity

cell-mediated immunity

cell-mediated immunity

cell-mediated immunity

cell-·me·di·at·ed im·mu·ni·ty (CMI),

cell-mediated immunity

cell-me·di·at·ed im·mu·ni·ty

cell-mediated immunity

cell-mediated immunity