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cryoglobulin
cryoglobulin (ˌkraɪəʊˈɡlɒbjʊlɪn) n (Biochemistry) med an abnormal immunoglobulin, present in the blood in certain diseases, that precipitates below about 10°C, obstructing small blood vessels in the fingers and toesTranslationscryoglobulin
cryoglobulin[¦krī·ō′gläb·yə·lən] (pathology) An abnormal protein, usually an immunoglobulin, which precipitates from plasma between 40 and 70°F (4.4 and 21°C). cryoglobulin
cryoglobulin [kri″o-glob´u-lin] a serum globulin (invariably an immunoglobulin) that precipitates at low temperature (e.g., 4°C) and redissolves at 37°C. Cryoglobulins are classified as Type I, monoclonal immunoglobulins; Type II, immune complexes involving monoclonal immunoglobulins with antibody activity against polyclonal immunoglobulins; or Type III, immune complexes involving polyclonal immunoglobulins (in most cases, these are globulin-antiglobulin immune complexes like Type II complexes). Types I and II occur in plasma cell dyscrasias and lymphoproliferative disorders as well as in asymptomatic “essential” cryoglobulinemia. Types II and III occur in autoimmune diseases such as arthritis" >rheumatoid arthritis, lupus erythematosus" >systemic lupus erythematosus, and Sjögren's syndrome. Type III also occurs in a wide variety of infectious diseases.cryoglobulin Hematology An abnormal protein–eg, polymeric IgG3, detected by cooling serum to 32ºC Found in Myeloma, Waldenström's macroglobulinemia, rheumatoid arthritis, Sjögren syndrome, CLL, SLE. See Cryoglobulinemia. CryoglobulinAn abnormal blood protein associated with several diseases. It is characterized by its tendency to clump in cold temperatures.Mentioned in: Cryoglobulin Test |