diffuse large cell lymphoma

one of the most common types of aggressive lymphoma, comprising about 20% of all cases of non-Hodgkin lymphoma; the patients' median age is 57 years. The cell of origin is the B lymphocyte despite its prior classification as one of the histiocytic lymphomas. About 20% of the cases have good evidence for a follicular center cell origin due to the presence of the BCL-2 gene rearrangement. As aggressive malignancies with a tendency to metastasize, most eventually demonstrate some extranodal component, including the gastrointestinal tract, testes, skin, central nervous system, or bone.

diffuse large cell lymphoma

(1) Diffuse large B-cell lymphoma (DLBCL), see there.

(2) A complex and heterogeneous group of non-Hodgkin lymphomas (NHLs), which includes the “histiocytic” lymphoma and reticulum cell sarcoma of older classifications, and affects patients around age 60. They are composed of round cells with little cytoplasm that may present in advanced stages. 80% of DLCLs are of B-cell lineage, 15% of T-cell origin and 5% unclassifiable. 20% may be accompanied by monoclonal gammopathy.

Prognosis
60% 5-year survival

单词	diffuse large cell lymphoma
释义	diffuse large cell lymphoma diffuse large cell lymphoma one of the most common types of aggressive lymphoma, comprising about 20% of all cases of non-Hodgkin lymphoma; the patients' median age is 57 years. The cell of origin is the B lymphocyte despite its prior classification as one of the histiocytic lymphomas. About 20% of the cases have good evidence for a follicular center cell origin due to the presence of the BCL-2 gene rearrangement. As aggressive malignancies with a tendency to metastasize, most eventually demonstrate some extranodal component, including the gastrointestinal tract, testes, skin, central nervous system, or bone. diffuse large cell lymphoma (1) Diffuse large B-cell lymphoma (DLBCL), see there. (2) A complex and heterogeneous group of non-Hodgkin lymphomas (NHLs), which includes the “histiocytic” lymphoma and reticulum cell sarcoma of older classifications, and affects patients around age 60. They are composed of round cells with little cytoplasm that may present in advanced stages. 80% of DLCLs are of B-cell lineage, 15% of T-cell origin and 5% unclassifiable. 20% may be accompanied by monoclonal gammopathy. Prognosis 60% 5-year survival AcronymsSeeDLCL
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