(klos-trid'ē-ŭm his'tō-lit'i-kŭm kō-lah'jen-ās), An enzyme that catalyzes the hydrolysis of collagen, preferentially at peptide bonds on the amino side of a glycylprolyl sequence. Synonym(s): clostridiopeptidase A, collagenase A, collagenase I, microbial collagenase