central dogma

cen·tral dog·ma

the proposition that while genetic information is transferred from parent to offspring via DNA duplication, within the cell, genetic information is transferred from DNA to mRNA (transcription) and then to protein (translation); proposed by Francis Crick.

The central dogma is the main thesis of molecular inheritance. In its simplest form, it states that DNA makes RNA, which makes protein; it is the pedagogical tenet that translation of a protein invariably follows a chain of molecular command, where DNA acts as the template for both its own replication and for the transcription to RNA—and, with subsequent maturation, to mRNA, which then serves as a template for translation into a protein

central dogma

Molecular biology The pedagogical tenet that translation of a protein invariably follows a chain of molecular command, where DNA acts as the template for both its own replication and for the transcription to RNA–and with subsequent maturation, to mRNA, which then serves as a template for translation into a protein. See DNA, Nucleic acid, Protein, Reverse transcription, RNA, RNA polymerase. Cf Prion.

central dogma

The proposition by Francis Crick (1916–) that, in genetics, the only possible progression was from DNA to RNA to protein. Embarrassingly, the discovery that retroviruses used RNA to make DNA demonstrated the riskiness of pronouncing dogmas in science.

central dogma

the hypothesis (based on WEISMANNISM) that genetical information flows only in one direction, from DNA to RNA to PROTEIN, and not in the opposite direction. Thus, in general, changes to protein structures produced by external forces are not inherited. See SOMATIC MUTATION. The hypothesis has, however, been modified to account for the activity of the enzyme REVERSE TRANSCRIPTASE, which transfers information ‘backwards’ from RNA to DNA.

单词	central dogma
释义	central dogma central dogma The core belief of a particular area of study. It is often used in molecular biology to describe the relationship between DNA, RNA, and proteins. The central dogma of molecular biology is that DNA makes RNA, which makes protein.See also: central central dogma central dogma [′sen·trəl ′dȯg·mə] (genetics) The concept, subject to several exceptions, that genetic information is coded in self-replicating deoxyribonucleic acid and undergoes unidirectional transfer to messenger ribonucleic acids in transcription that act as templates for protein synthesis in translation. central dogma cen·tral dog·ma the proposition that while genetic information is transferred from parent to offspring via DNA duplication, within the cell, genetic information is transferred from DNA to mRNA (transcription) and then to protein (translation); proposed by Francis Crick. The central dogma is the main thesis of molecular inheritance. In its simplest form, it states that DNA makes RNA, which makes protein; it is the pedagogical tenet that translation of a protein invariably follows a chain of molecular command, where DNA acts as the template for both its own replication and for the transcription to RNA—and, with subsequent maturation, to mRNA, which then serves as a template for translation into a protein central dogma Molecular biology The pedagogical tenet that translation of a protein invariably follows a chain of molecular command, where DNA acts as the template for both its own replication and for the transcription to RNA–and with subsequent maturation, to mRNA, which then serves as a template for translation into a protein. See DNA, Nucleic acid, Protein, Reverse transcription, RNA, RNA polymerase. Cf Prion. central dogma The proposition by Francis Crick (1916–) that, in genetics, the only possible progression was from DNA to RNA to protein. Embarrassingly, the discovery that retroviruses used RNA to make DNA demonstrated the riskiness of pronouncing dogmas in science. central dogma the hypothesis (based on WEISMANNISM) that genetical information flows only in one direction, from DNA to RNA to PROTEIN, and not in the opposite direction. Thus, in general, changes to protein structures produced by external forces are not inherited. See SOMATIC MUTATION. The hypothesis has, however, been modified to account for the activity of the enzyme REVERSE TRANSCRIPTASE, which transfers information ‘backwards’ from RNA to DNA.
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