famciclovir

[fam-si´klo-vir] a prodrug of penciclovir that is converted to the active drug following administration, used in the treatment of herpes zoster, of genital herpes, and of mucocutaneous herpes simplex in immunocompromised patients; administered orally.

famciclovir

Apo-Famciclovir (CA), Famvir, PMS-Famciclovir (CA), Sandoz Famciclovir (CA)

Pharmacologic class: Synthetic nucleoside

Therapeutic class: Antiviral

Pregnancy risk category B

Action

Converts to penciclovir and selectively inhibits DNA polymerase and viral DNA synthesis

Availability

Tablets: 125 mg, 250 mg, 500 mg

Indications and dosages

➣ Acute herpes zoster infection (shingles)

Adults: 500 mg P.O. q 8 hours for 7 days

➣ Recurrent genital herpes in immunocompetent patients

Adults: 1,000 mg P.O. b.i.d. for 1 day, starting as soon as symptoms appear

➣ Suppression of recurrent genital herpes

Adults: 250 mg P.O. b.i.d. for up to 1 year

➣ Recurrent herpes simplex infection in patients with human immunodeficiency virus

Adults: 500 mg P.O. b.i.d. for 7 days

➣ Herpes labialis (oral herpes simplex) in immunocompetent patients

Adults: 1,500 mg P.O. as a one-time dose given as soon as symptoms appear

Dosage adjustment

• Renal impairment

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:

• renal or hepatic impairment

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 18.

Administration

• Know that for best response, therapy should begin within 6 hours of onset of genital herpes symptoms or lesions.

• Give with or without food.

Adverse reactions

CNS: headache, fatigue, dizziness, drowsiness, paresthesia, insomnia

EENT: pharyngitis, sinusitis

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, anorexia

Musculoskeletal: back pain, joint pain

Skin: pruritus, rash

Other: fever

Interactions

Drug-drug. Digoxin: increased digoxin blood level, increased risk of toxicity

Probenecid: increased blood level of penciclovir (active antiviral compound of famciclovir)

Patient monitoring

• When giving concurrently with digoxin, monitor digoxin blood level and evaluate for digoxin toxicity.

• Monitor CBC, blood urea nitrogen, creatinine, and electrolyte levels.

• Be aware that drug may take several weeks to reach therapeutic level.

• Know that renal failure may raise blood drug level, increasing the risk of adverse reactions.

• Avoid direct contact with infected areas. Wash hands frequently and wear gloves during patient contact.

Patient teaching

• Instruct patient to take with food or milk to avoid upset stomach.

• Inform patient that drug doesn't cure herpes but only decreases pain and itching by allowing sores to heal and preventing new ones from forming.

• Advise patient to wear loose-fitting clothing to avoid irritating lesions.

• Tell patient to report rash or itching.

• Instruct female patient to tell prescriber if she is pregnant or breastfeeding.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

famciclovir

(făm-sī′klō-vîr′)n. A synthetic nucleoside analog, C₁₄H₁₉N₅O₄, used to treat herpes simplex and herpes zoster infections.

famciclovir

An antiviral drug used to treat SHINGLES and genital HERPES. A brand name is Famvir.

Famciclovir

An oral antiviral drug that is available under the trade name Famvir. The drug blocks the replication of the varicella zoster virus.Mentioned in: Shingles

单词	famciclovir
释义	famciclovir fam·ci·clo·vir F5026300 (făm-sī′klō-vîr′)n. A synthetic nucleoside analog, C₁₄H₁₉N₅O₄, used to treat herpes simplex and herpes zoster infections. [fam-, origin unknown + -ciclovir, antiviral drug suffix (from acyclovir).] Translations famciclovir famciclovir [fam-si´klo-vir] a prodrug of penciclovir that is converted to the active drug following administration, used in the treatment of herpes zoster, of genital herpes, and of mucocutaneous herpes simplex in immunocompromised patients; administered orally. famciclovir Apo-Famciclovir (CA), Famvir, PMS-Famciclovir (CA), Sandoz Famciclovir (CA) *Pharmacologic class:* Synthetic nucleoside *Therapeutic class:* Antiviral *Pregnancy risk category B* Action Converts to penciclovir and selectively inhibits DNA polymerase and viral DNA synthesis Availability Tablets: 125 mg, 250 mg, 500 mg Indications and dosages ➣ Acute herpes zoster infection (shingles) Adults: 500 mg P.O. q 8 hours for 7 days ➣ Recurrent genital herpes in immunocompetent patients Adults: 1,000 mg P.O. b.i.d. for 1 day, starting as soon as symptoms appear ➣ Suppression of recurrent genital herpes Adults: 250 mg P.O. b.i.d. for up to 1 year ➣ Recurrent herpes simplex infection in patients with human immunodeficiency virus Adults: 500 mg P.O. b.i.d. for 7 days ➣ Herpes labialis (oral herpes simplex) in immunocompetent patients Adults: 1,500 mg P.O. as a one-time dose given as soon as symptoms appear Dosage adjustment • Renal impairment Contraindications • Hypersensitivity to drug or its components Precautions Use cautiously in: • renal or hepatic impairment • elderly patients • pregnant or breastfeeding patients • children younger than age 18. Administration • Know that for best response, therapy should begin within 6 hours of onset of genital herpes symptoms or lesions. • Give with or without food. Adverse reactions CNS: headache, fatigue, dizziness, drowsiness, paresthesia, insomnia EENT: pharyngitis, sinusitis GI: nausea, vomiting, diarrhea, constipation, abdominal pain, anorexia Musculoskeletal: back pain, joint pain Skin: pruritus, rash Other: fever Interactions Drug-drug. Digoxin: increased digoxin blood level, increased risk of toxicity Probenecid: increased blood level of penciclovir (active antiviral compound of famciclovir) Patient monitoring • When giving concurrently with digoxin, monitor digoxin blood level and evaluate for digoxin toxicity. • Monitor CBC, blood urea nitrogen, creatinine, and electrolyte levels. • Be aware that drug may take several weeks to reach therapeutic level. • Know that renal failure may raise blood drug level, increasing the risk of adverse reactions. • Avoid direct contact with infected areas. Wash hands frequently and wear gloves during patient contact. Patient teaching • Instruct patient to take with food or milk to avoid upset stomach. • Inform patient that drug doesn't cure herpes but only decreases pain and itching by allowing sores to heal and preventing new ones from forming. • Advise patient to wear loose-fitting clothing to avoid irritating lesions. • Tell patient to report rash or itching. • Instruct female patient to tell prescriber if she is pregnant or breastfeeding. • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above. famciclovir (făm-sī′klō-vîr′)n. A synthetic nucleoside analog, C₁₄H₁₉N₅O₄, used to treat herpes simplex and herpes zoster infections. famciclovir An antiviral drug used to treat SHINGLES and genital HERPES. A brand name is Famvir. Famciclovir An oral antiviral drug that is available under the trade name Famvir. The drug blocks the replication of the varicella zoster virus.Mentioned in: Shingles
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famciclovir

fam·ci·clo·vir

famciclovir

famciclovir

famciclovir

Action

Availability

Indications and dosages

Dosage adjustment

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

famciclovir

famciclovir

Famciclovir