| 单词 | familial dysbetalipoproteinemia |
| 释义 | familial dysbetalipoproteinemiadysbetalipoproteinemia[dis-ba″tah-lip″o-pro″tēn-e´me-ah]familial dysbetalipoproteinemiaBroad beta lipoproteinemia, hyperlipoproteinemia type III Metabolic disease An uncommon 1:1,000 to 10,000 AD condition with a defective apoE–the apoE2/2 phenotype, poor catabolism of beta-migrating remnants, and ↑ production of TG-rich lipoproteins–eg, VLDL Clinical Palmoplantar tuberoeruptive xanthomas, ASHD < age 50, peripheral vascular and CAD, which may be accompanied by hyperthyroidism Lab ↑ TGs, ↑ cholesterol, floating beta lipoproteins Management Diet–weight loss, exercise, drugs–eg bile acid-binding resins and nicotinic acid; in post-menopausal ♀, low-dose estrogens |
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