biological containment

Any measure used to prevent the replication of recombinant DNA in microorganisms in nature and confine genetically engineered organisms to the lab, by creating biological barriers that prevent their growth outside. Biocontainment strategies include using vectors and host organisms that have been modified to minimise their survival outside of the laboratory.

biological containment

Steps taken to prevent the free replication of laboratory-produced recombinant DNA in the natural environment. A principal method is to use vectors and hosts that have been so modified that they will not survive outside the laboratory.

biological containment

methods of protecting the environment from potentially dangerous experimental laboratory organisms. Host ORGANISMS and their VECTORS used in GENETIC ENGINEERING are often developed with special characteristics to enable them to be contained biologically. This may involve the introduction of MUTATIONS that partly disable the organism and vector, thus preventing survival in the natural environment should they escape from the laboratory For example, the host may require certain nutrients that are available in the laboratory but not in the natural environment; it may be sensitive to UV irradiation, or to BILE salts (found in the human GUT); while the vector may be prevented from transferring to other organisms in the environment should it be released. Controllable SUICIDE GENES may be introduced into an organism in such a way that their EXPRESSION can be activated, when the need arises, in order to eliminate the organism.

单词	biological containment
释义	biological containment biological containment [¦bī·ə¦läj·ə·kəl kən′tān·mənt] (genetics) A technique by which the genetic constitution of an organism is altered in order to minimize its ability to grow outside the laboratory. Also known as biocontainment. biological containment biological containment Any measure used to prevent the replication of recombinant DNA in microorganisms in nature and confine genetically engineered organisms to the lab, by creating biological barriers that prevent their growth outside. Biocontainment strategies include using vectors and host organisms that have been modified to minimise their survival outside of the laboratory. biological containment Steps taken to prevent the free replication of laboratory-produced recombinant DNA in the natural environment. A principal method is to use vectors and hosts that have been so modified that they will not survive outside the laboratory. biological containment biological containment methods of protecting the environment from potentially dangerous experimental laboratory organisms. Host ORGANISMS and their VECTORS used in GENETIC ENGINEERING are often developed with special characteristics to enable them to be contained biologically. This may involve the introduction of MUTATIONS that partly disable the organism and vector, thus preventing survival in the natural environment should they escape from the laboratory For example, the host may require certain nutrients that are available in the laboratory but not in the natural environment; it may be sensitive to UV irradiation, or to BILE salts (found in the human GUT); while the vector may be prevented from transferring to other organisms in the environment should it be released. Controllable SUICIDE GENES may be introduced into an organism in such a way that their EXPRESSION can be activated, when the need arises, in order to eliminate the organism.
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