DUSP26

A gene on chromosome 8p12 that encodes putative dual-specificity phosphatase 26, which inactivates MAPK1 and MAPK3, leading to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. DUSP26 inhibits MAP kinase p38/MAPK14 by dephosphorylating it and inhibiting p38-mediated apoptosis in anaplastic thyroid carcinoma; it also activates MAP kinases p38/MAPK14 and JNK/MAPK8. DUSP26 is also a less preferred gene symbol for what is now designated as DUSP28, see there.
Molecular pathology
DUSP26 is expressed in embryonal cancers (retinoblastoma, neuroepithelioma, neuroblastoma) and in anaplatic thyroid carcinoma

单词	dusp26
释义	DUSP26 DUSP26 A gene on chromosome 8p12 that encodes putative dual-specificity phosphatase 26, which inactivates MAPK1 and MAPK3, leading to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. DUSP26 inhibits MAP kinase p38/MAPK14 by dephosphorylating it and inhibiting p38-mediated apoptosis in anaplastic thyroid carcinoma; it also activates MAP kinases p38/MAPK14 and JNK/MAPK8. DUSP26 is also a less preferred gene symbol for what is now designated as DUSP28, see there. Molecular pathology DUSP26 is expressed in embryonal cancers (retinoblastoma, neuroepithelioma, neuroblastoma) and in anaplatic thyroid carcinoma
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