dihydrolipoamide dehydrogenase


di·hy·dro·lip·o·am·ide de·hy·dro·gen·ase

(dī-hī'drō-lip-ō-am'id dē-hī'drō-jen-ās'), A flavoenzyme oxidizing dihydrolipoamide at the expense of NAD+; completes the oxidative decarboxylation of pyruvate; a part of several enzyme complexes (for example, α-ketoglutarate dehydrogenase complex). Decreased activity leads to neuronal loss in brain resulting in psychomotor retardation. Synonym(s): coenzyme factor, lipoamide dehydrogenase, lipoamide reductase (NADH), lipoyl dehydrogenase

dihydrolipoamide dehydrogenase

(di?hi?dro-lip?o-am'id?) The flavoprotein catalyst of the reoxidation of nicotinamide-adenine dinucleotide (NAD) or nicotinamide-adenine dinucleotide phosphate (NADP) by the mitochondrial electron transport chain. Synonym: diaphorase