Ceruloplasmin

ceruloplasmin

[sə¦rül·ō¦plaz·mən] (biochemistry) The copper-binding serum protein in human blood.

Ceruloplasmin

a copper-containing protein of the α₂-globulin fraction of blood plasma. It was first discovered and isolated by the Swedish scientists C. Holmberg and C. Laurell in 1948. Its content in human plasma is 0.2–0.3 mg/ml. Ceruloplas-min, which has a molecular weight of 130,000, is bound to 60–99 percent of all the plasma copper ions. Its two molecular forms differ in the number of carbohydrate chains, which consist of galactose, mannose, fucose, N-acetylglucosamine, and sialic-acid residues. Ceruloplasmin has some catalytic activity, oxidizing polyamines, polyphenols, and ascorbic acid (vitamin C). It also takes part in hematopoiesis and the transport of copper to sites where other copper-containing proteins, such as cytochromoe oxidases, are synthesized. In addition, it apparently participates in the regulation of the level of biogenic amines.

There exist genetically determined variants of ceruloplasmin caused by the presence of mutant alleles. The level of ceruloplas-min in blood serum increases nonspecifically during pregnancy, infections, anemias, and malignancies but decreases during the Wilson-Konovalov disease and some other diseases.

N. N. CHERNOV

ceruloplasmin

enUK

ceruloplasmin

[sĕ-roo″lo-plaz´min] an alpha₂-globulin of the plasma, being the form in which most of the plasma copper is transported.

ce·ru·lo·plas·min

(sĕ-rū'lō-plaz'min), [MIM*117700] A blue, copper-containing α-globulin of blood plasma, with a molecular weight of about 122,000 and 6 or 7 atoms of copper per molecule; involved in copper transport and regulation, and can reduce O₂ directly without known intermediates; has ferroxidase and polyamine oxidase activities. Ceruloplasmin is absent in congenital Wilson disease. [L. caeruleus, dark blue]

ceruloplasmin

(sə-ro͞o′lō-plăz′mĭn)n. A blood glycoprotein to which copper is bound during transport and storage.

ceruloplasmin

Ferroxidase Clinical chemistry A dehydrogenase produced in the liver involved in copper detoxification and possibly in mopping up excess oxygen radicals or superoxide anions ↑ in Neoplasms, inflammation, liver disease, rheumatoid arthritis, SLE, pregnancy, OCs, estrogen therapy ↓ in Wilson's disease, Menkes' kinky hair syndrome, hepatitis, cirrhosis, nephrotic syndrome, sprue, scleroderma of small intestine. See Copper.

ce·ru·lo·plas·min

(sĕ-rū'lō-plaz'min) A blue, copper-containing alpha-globulin of blood plasma; involved in copper transport and regulation, and can reduce O₂ directly without known intermediates. Ceruloplasmin is absent in congenital Wilson disease. [L. caeruleus, dark blue]

Ceruloplasmin

A protein circulating in the bloodstream that binds with copper and transports it.Mentioned in: Wilson Disease

单词	ceruloplasmin
释义	ceruloplasmin enUK ce·ru·lo·plas·min C0215500 (sə-ro͞o′lō-plăz′mĭn)n. A blood glycoprotein to which copper is bound during transport and storage. [cerul(ean) + plasm(a) + -in.] ceruloplasmin (sɪˌruːləʊˈplæzmɪn) na protein responsible for copper detoxification, found in the blood Ceruloplasmin enUK ceruloplasmin [sə¦rül·ō¦plaz·mən] (biochemistry) The copper-binding serum protein in human blood. Ceruloplasmin a copper-containing protein of the α₂-globulin fraction of blood plasma. It was first discovered and isolated by the Swedish scientists C. Holmberg and C. Laurell in 1948. Its content in human plasma is 0.2–0.3 mg/ml. Ceruloplas-min, which has a molecular weight of 130,000, is bound to 60–99 percent of all the plasma copper ions. Its two molecular forms differ in the number of carbohydrate chains, which consist of galactose, mannose, fucose, N-acetylglucosamine, and sialic-acid residues. Ceruloplasmin has some catalytic activity, oxidizing polyamines, polyphenols, and ascorbic acid (vitamin C). It also takes part in hematopoiesis and the transport of copper to sites where other copper-containing proteins, such as cytochromoe oxidases, are synthesized. In addition, it apparently participates in the regulation of the level of biogenic amines. There exist genetically determined variants of ceruloplasmin caused by the presence of mutant alleles. The level of ceruloplas-min in blood serum increases nonspecifically during pregnancy, infections, anemias, and malignancies but decreases during the Wilson-Konovalov disease and some other diseases. N. N. CHERNOV ceruloplasmin enUK ceruloplasmin [sĕ-roo″lo-plaz´min] an alpha₂-globulin of the plasma, being the form in which most of the plasma copper is transported. ce·ru·lo·plas·min (sĕ-rū'lō-plaz'min), [MIM117700] A blue, copper-containing α-globulin of blood plasma, with a molecular weight of about 122,000 and 6 or 7 atoms of copper per molecule; involved in copper transport and regulation, and can reduce O₂ directly without known intermediates; has ferroxidase and polyamine oxidase activities. Ceruloplasmin is absent in congenital Wilson disease. [L. caeruleus,* dark blue] ceruloplasmin (sə-ro͞o′lō-plăz′mĭn)n. A blood glycoprotein to which copper is bound during transport and storage. ceruloplasmin Ferroxidase Clinical chemistry A dehydrogenase produced in the liver involved in copper detoxification and possibly in mopping up excess oxygen radicals or superoxide anions ↑ in Neoplasms, inflammation, liver disease, rheumatoid arthritis, SLE, pregnancy, OCs, estrogen therapy ↓ in Wilson's disease, Menkes' kinky hair syndrome, hepatitis, cirrhosis, nephrotic syndrome, sprue, scleroderma of small intestine. See Copper. ce·ru·lo·plas·min (sĕ-rū'lō-plaz'min) A blue, copper-containing alpha-globulin of blood plasma; involved in copper transport and regulation, and can reduce O₂ directly without known intermediates. Ceruloplasmin is absent in congenital Wilson disease. [L. caeruleus, dark blue] Ceruloplasmin A protein circulating in the bloodstream that binds with copper and transports it.Mentioned in: Wilson Disease AcronymsSeecopilot
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