dornase alfa

[dor´nāz al´fah] recombinant human deoxyribonuclease I (DNase I) used to reduce the viscosity of sputum in cystic fibrosis patients; administered by inhalation.

dornase alfa

Pulmozyme

Pharmacologic class: Recombinant human deoxyribonuclease I

Therapeutic class: Cystic fibrosis agent, mucolytic enzyme, respiratory inhalant

Pregnancy risk category B

Action

Selectively cleaves to DNA in sputum, decreasing viscosity of pulmonary secretions

Availability

Inhalation solution: 2.5-mg ampule (1 mg/ml)

Indications and dosages

➣ To reduce respiratory tract infections and improve pulmonary function in patients with cystic fibrosis

Adults and children: One ampule (2.5 mg) inhaled once daily; some patients may benefit from twice-daily dosing. Safety and efficacy of daily administration haven't been demonstrated for longer than 12 months.

Contraindications

• Hypersensitivity to drug, its components, or products derived from Chinese hamster ovary cells

Precautions

Use cautiously in:

• pregnant or breastfeeding patients.

Administration

• Don't shake, dilute, or mix with other drugs.

• Use only with approved nebulizer.

• Discard cloudy or discolored solution.

Adverse reactions

CV: chest pain

EENT: conjunctivitis, rhinitis, pharyngitis, hemoptysis, voice changes

Respiratory: dyspnea, increased sputum, wheezing

Skin: rash, urticaria, pruritus

Other: hypersensitivity reactions

Interactions

None known

Patient monitoring

• Assess patient periodically. Report improvement in dyspnea and sputum clearance.

• Monitor for signs and symptoms of hypersensitivity reaction.

Patient teaching

• Teach patient how to use nebulizer.

• Instruct patient to report rash, hives, and itching.

• As appropriate, review all other significant adverse reactions mentioned above.

dornase alfa

(dôr′nās′ ăl′fə, -nāz′)n. A genetically engineered enzyme used to hydrolyze the DNA in bronchial mucus, facilitating its expectoration, in the treatment of cystic fibrosis.

dornase alfa

A drug used to remove sticky and tenacious secretions from the air passages of people suffering from CYSTIC FIBROSIS. A brand name is Pulmozyme.

单词	dornase alfa
释义	dornase alfa dor·nase al·fa D0346450 (dôr′nās′ ăl′fə, -nāz′)n. A genetically engineered enzyme used to hydrolyze the DNA in bronchial mucus, facilitating its expectoration, in the treatment of cystic fibrosis. [(recombinant human) d(e)o(xy)r(ibo)n(ucle)ase (1) + alteration of alpha.] dornase alfa dornase alfa [dor´nāz al´fah] recombinant human deoxyribonuclease I (DNase I) used to reduce the viscosity of sputum in cystic fibrosis patients; administered by inhalation. dornase alfa Pulmozyme *Pharmacologic class:* Recombinant human deoxyribonuclease I *Therapeutic class:* Cystic fibrosis agent, mucolytic enzyme, respiratory inhalant *Pregnancy risk category B* Action Selectively cleaves to DNA in sputum, decreasing viscosity of pulmonary secretions Availability Inhalation solution: 2.5-mg ampule (1 mg/ml) Indications and dosages ➣ To reduce respiratory tract infections and improve pulmonary function in patients with cystic fibrosis Adults and children: One ampule (2.5 mg) inhaled once daily; some patients may benefit from twice-daily dosing. Safety and efficacy of daily administration haven't been demonstrated for longer than 12 months. Contraindications • Hypersensitivity to drug, its components, or products derived from Chinese hamster ovary cells Precautions Use cautiously in: • pregnant or breastfeeding patients. Administration • Don't shake, dilute, or mix with other drugs. • Use only with approved nebulizer. • Discard cloudy or discolored solution. Adverse reactions CV: chest pain EENT: conjunctivitis, rhinitis, pharyngitis, hemoptysis, voice changes Respiratory: dyspnea, increased sputum, wheezing Skin: rash, urticaria, pruritus Other: hypersensitivity reactions Interactions None known Patient monitoring • Assess patient periodically. Report improvement in dyspnea and sputum clearance. • Monitor for signs and symptoms of hypersensitivity reaction. Patient teaching • Teach patient how to use nebulizer. • Instruct patient to report rash, hives, and itching. • As appropriate, review all other significant adverse reactions mentioned above. dornase alfa (dôr′nās′ ăl′fə, -nāz′)n. A genetically engineered enzyme used to hydrolyze the DNA in bronchial mucus, facilitating its expectoration, in the treatment of cystic fibrosis. dornase alfa A drug used to remove sticky and tenacious secretions from the air passages of people suffering from CYSTIC FIBROSIS. A brand name is Pulmozyme.
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dornase alfa

dor·nase al·fa

dornase alfa

dornase alfa

dornase alfa

Action

Availability

Indications and dosages

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

dornase alfa

dornase alfa