APC resistance

Activated Protein C Resistance

An inherited (autosomal dominant) or acquired defect in the anticoagulant response to activated protein C, resulting in an increased risk of thrombosis.
Clinical findings Increased risk of deep vein thrombosis (DVT), venous thrombosis; it is responsible for 20% to 50% of DVT.
Pathogenesis Protein C, a key regulator of coagulation, circulates in an inactivated form and is activated by the binding of thrombin to thrombomodulin receptors on vascular endothelial cells; once activated, protein C lyses coagulation factors Va and VIIIa. Activated protein C resistance is caused by a failure of protein C to cleave Factor Va and/or Factor VIIIa.

APC resistance

Activated protein C resistance, see there.

APC resistance

Abbrev. for activated protein C resistance, an abnormal tendency to blood clotting caused by a mutation in the gene for blood clotting factor V. This mutation is known as the FACTOR V LEIDEN MUTATION. APC resistance is the commonest cause of inherited THROMBOPHILIA.

单词	apc resistance
释义	APC resistance Activated Protein C Resistance An inherited (autosomal dominant) or acquired defect in the anticoagulant response to activated protein C, resulting in an increased risk of thrombosis. Clinical findings Increased risk of deep vein thrombosis (DVT), venous thrombosis; it is responsible for 20% to 50% of DVT. Pathogenesis Protein C, a key regulator of coagulation, circulates in an inactivated form and is activated by the binding of thrombin to thrombomodulin receptors on vascular endothelial cells; once activated, protein C lyses coagulation factors Va and VIIIa. Activated protein C resistance is caused by a failure of protein C to cleave Factor Va and/or Factor VIIIa. APC resistance Activated protein C resistance, see there. APC resistance Abbrev. for activated protein C resistance, an abnormal tendency to blood clotting caused by a mutation in the gene for blood clotting factor V. This mutation is known as the FACTOR V LEIDEN MUTATION. APC resistance is the commonest cause of inherited THROMBOPHILIA.
随便看	health human resources planning health human resources unit health identification card healthier healthier black elders center healthier communities, older people healthier people health risk appraisal healthiest healthily health impact assessment health impact assessment research unit health improvement and modernisation plan health improvement and modernisation plans health improvement and modernisation programme health improvement, efficiency & governance, access, treatment targets health improvement institute health improvement institute quality award health improvement partnership health improvement program health improvement programme health in action health incident management team health indicator health indicators conceptual framework health indicator test