dipyridamole

[di″pi-rid´ah-mōl] a inhibitor" >platelet inhibitor and coronary vasodilator, used to prevent clotting associated with mechanical heart valves and to treat transient ischemic attacks. It is also used as an adjunct in the prevention of myocardial reinfarction and as an adjunct in radionuclide myocardial perfusion imaging.

dipyridamole

Apo-Dipyridamole FC (CA), Apo-Dipyridamole SC (CA), Persantin (UK), Persantine

Pharmacologic class: Platelet adhesion inhibitor

Therapeutic class: Antiplatelet agent, diagnostic agent (coronary vasodilator)

Pregnancy risk category B

Action

Unclear. May reduce platelet aggregation by inhibiting phosphodiesterase, adenosine uptake, or formation of thromboxane A₂.

Availability

Tablets: 25 mg, 50 mg, 75 mg

Indications and dosages

➣ To prevent thromboembolism in patients with prosthetic heart valves

Adults: 75 to 100 mg P.O. q.i.d.

Off-label uses

• Prevention of myocardial reinfarction (given with aspirin)

• Thrombotic thrombocytopenia purpura

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:

• hypotension, hepatic insufficiency, severe coronary artery disease

• pregnant or breastfeeding patients

• children younger than age 12 (safety not established).

Administration

• Know that drug is usually given with warfarin when used to prevent thromboembolism.

• Give with a full glass of water at least 1 hour before or 2 hours after meals. If gastric distress occurs, give with food.

Adverse reactions

CNS: dizziness, headache

CV: hypotension

GI: abdominal distress

Hepatic: hepatic failure

Skin: rash

Interactions

Drug-drug. Adenosine: increased adenosine plasma level and CV effects

Cholinesterase inhibitors: counteracts activity of cholinesterase inhibitors

Drug-diagnostic tests. Hepatic enzymes: increased levels

Drug-behaviors. Alcohol use: increased risk of hypotension

Patient monitoring

• Monitor for therapeutic efficacy, including improved exercise tolerance and decreased need for nitrates.

• Assess platelet and coagulation studies regularly.

• Monitor ECG and vital signs, especially blood pressure.

• Monitor hepatic function tests regularly.

Patient teaching

• Advise patient to take drug 1 hour before or 2 hours after meals for best absorption.

See Instruct patient to immediately report unusual tiredness, chest pain or other cardiac symptoms, upper right abdominal pain, yellowing of skin or eyes, or dark urine.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

dipyridamole

(dī-pĭr′ĭ-də-mōl′, dī′pə-rĭd′ə-mōl′)n. A drug, C₂₄H₄₀N₈O₄, that acts as a coronary vasodilator and is used in the long-term treatment of angina pectoris and as an antiplatelet agent.

dipyridamole

A drug used to reduce platelet stickiness and thus the risk of STROKE in people having TRANSIENT ISCHAEMIC ATTACKS. Aspirin is more effective, but sometimes cannot be safely taken. A brand name is Persantin.

单词	dipyridamole
释义	dipyridamole di·pyr·id·a·mole D0242800 (dī-pĭr′ĭ-də-mōl′, dī′pə-rĭd′ə-mōl′)n. A drug, C₂₄H₄₀N₈O₄, that acts as a coronary vasodilator and is used in the long-term treatment of angina pectoris and as an antiplatelet agent. [di- + pyrid(ine) + -am(ine) + -ole.] Translations dipyridamole dipyridamole [di″pi-rid´ah-mōl] a inhibitor" >platelet inhibitor and coronary vasodilator, used to prevent clotting associated with mechanical heart valves and to treat transient ischemic attacks. It is also used as an adjunct in the prevention of myocardial reinfarction and as an adjunct in radionuclide myocardial perfusion imaging. dipyridamole Apo-Dipyridamole FC (CA), Apo-Dipyridamole SC (CA), Persantin (UK), Persantine *Pharmacologic class:* Platelet adhesion inhibitor *Therapeutic class:* Antiplatelet agent, diagnostic agent (coronary vasodilator) *Pregnancy risk category B* Action Unclear. May reduce platelet aggregation by inhibiting phosphodiesterase, adenosine uptake, or formation of thromboxane A₂. Availability Tablets: 25 mg, 50 mg, 75 mg Indications and dosages ➣ To prevent thromboembolism in patients with prosthetic heart valves Adults: 75 to 100 mg P.O. q.i.d. Off-label uses • Prevention of myocardial reinfarction (given with aspirin) • Thrombotic thrombocytopenia purpura Contraindications • Hypersensitivity to drug Precautions Use cautiously in: • hypotension, hepatic insufficiency, severe coronary artery disease • pregnant or breastfeeding patients • children younger than age 12 (safety not established). Administration • Know that drug is usually given with warfarin when used to prevent thromboembolism. • Give with a full glass of water at least 1 hour before or 2 hours after meals. If gastric distress occurs, give with food. Adverse reactions CNS: dizziness, headache CV: hypotension GI: abdominal distress Hepatic: hepatic failure Skin: rash Interactions Drug-drug. Adenosine: increased adenosine plasma level and CV effects Cholinesterase inhibitors: counteracts activity of cholinesterase inhibitors Drug-diagnostic tests. Hepatic enzymes: increased levels Drug-behaviors. Alcohol use: increased risk of hypotension Patient monitoring • Monitor for therapeutic efficacy, including improved exercise tolerance and decreased need for nitrates. • Assess platelet and coagulation studies regularly. • Monitor ECG and vital signs, especially blood pressure. • Monitor hepatic function tests regularly. Patient teaching • Advise patient to take drug 1 hour before or 2 hours after meals for best absorption. See Instruct patient to immediately report unusual tiredness, chest pain or other cardiac symptoms, upper right abdominal pain, yellowing of skin or eyes, or dark urine. • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above. dipyridamole (dī-pĭr′ĭ-də-mōl′, dī′pə-rĭd′ə-mōl′)n. A drug, C₂₄H₄₀N₈O₄, that acts as a coronary vasodilator and is used in the long-term treatment of angina pectoris and as an antiplatelet agent. dipyridamole A drug used to reduce platelet stickiness and thus the risk of STROKE in people having TRANSIENT ISCHAEMIC ATTACKS. Aspirin is more effective, but sometimes cannot be safely taken. A brand name is Persantin.
随便看	leroy l hartman leroy percy state park le roy public library leroy robert paige leroy thompson ministerial alliance leroy vinnegar jazz institute le roy, édouard lerp lerpc lerp (computing) lerpnet lerpwl lerr lerrd lerroux, alejandro lers lersl lersm lersse lert lerta lertcon lerts leru ler ut høyt

dipyridamole

di·pyr·id·a·mole

dipyridamole

dipyridamole

dipyridamole

Action

Availability

Indications and dosages

Off-label uses

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

dipyridamole

dipyridamole