eotaxin

eotaxin

(ē'ō-tak-sin), A chemokine with chemoattractant properties for eosinophils, but not for leukocytes. [eosinophil + G. taxis, orderly arrangement, + -in]

CCL11

A gene on chromosome 17q21.1-q21.2 that encodes eotaxin-1, a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. Eotaxin-1/CCL11 binds CCR3, is chemotactic for eosinophils—but not mononuclear cells or neutrophils—and is involved in eosinophilic type inflammatory responses (e.g., atopic dermatitis, allergic rhinitis, asthma and parasitic infections).

eotaxin

(e-o-toks'in) [Gr. eos, dawn (rose-colored) + (chemo)taxin] A chemokine that specifically attracts eosinophils to particular tissues (e.g., to bronchial tissues in asthma or to the skin in contact dermatitis). Tumor necrosis factor alpha stimulates its release. See: chemotaxis; cytokine