EP300

A gene on chromosome 22q13.2 that encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein, which acts as a histone acetyltransferase, regulating transcription via chromatin remodelling; it is important in cell proliferation and differentiation. EP300 is a co-activator of HIF1A (hypoxia-inducible factor-1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes (e.g., VEGF).

Molecular pathology
EP300 mutations are the cause of Rubinstein-Taybi syndrome and may play a role in epithelial malignancies.

单词	ep300
释义	EP300 EP300 A gene on chromosome 22q13.2 that encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein, which acts as a histone acetyltransferase, regulating transcription via chromatin remodelling; it is important in cell proliferation and differentiation. EP300 is a co-activator of HIF1A (hypoxia-inducible factor-1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes (e.g., VEGF). Molecular pathology EP300 mutations are the cause of Rubinstein-Taybi syndrome and may play a role in epithelial malignancies.
随便看	cpsms cpsmt cpsn cpsnb cpsnl c. p. snow cp snow cpsns cpso cpsoa cpsos cpsp cpspp cpsqa cpsr cpsrb cpsre cpsrn cpsrs cpsrt cpsrta cp-ss cp/ss cpss cpssd