F2RL1

A gene on chromosome 5q13 that encodes a widely expressed G protein-coupled receptor for trypsin and trypsin-like enzymes. F2RL1 helps recruit leukocytes to the sites of inflammation, and is the major protease-activated receptor (PAR) capable of modulating eosinophil function (e.g., proinflammatory cytokine secretion, superoxide production and degranulation). During inflammation, it promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. It is involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of gram-positive and killing of gram-negative bacteria. F2RL1 acts synergistically with IFN-gamma to enhance antiviral responses. It appears to play a role in inflammatory disorders of the joints, lungs, brain, GI tract, periodontium, skin and vascular systems, and in autoimmune disorders

单词	f2rl1
释义	F2RL1 F2RL1 A gene on chromosome 5q13 that encodes a widely expressed G protein-coupled receptor for trypsin and trypsin-like enzymes. F2RL1 helps recruit leukocytes to the sites of inflammation, and is the major protease-activated receptor (PAR) capable of modulating eosinophil function (e.g., proinflammatory cytokine secretion, superoxide production and degranulation). During inflammation, it promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. It is involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of gram-positive and killing of gram-negative bacteria. F2RL1 acts synergistically with IFN-gamma to enhance antiviral responses. It appears to play a role in inflammatory disorders of the joints, lungs, brain, GI tract, periodontium, skin and vascular systems, and in autoimmune disorders
随便看	solid-state membrane electrode solid state memory solid-state memory solid state modification of porous structures solidstate modular system solid-state nuclear magnetic resonance solid-state nuclear track detector solid (state of matter) solid state overload relay solid-state over voltage protector solid state phased array radar solid state phased array radar system solid state photomultipliers solid-state physicist solid state physics solid-state physics solid-state physics, institute of salomon brothers non-us dollar world government bond index salomon brothers world equity index salomon de goyer salomon farley acree salomon gessner salomon, haym salomonica salomon maimon