acute lobular hepatitis

Liver inflammation of abrupt onset, which is characterised by patchy confluent pan- and multi-acinar necrosis, with loss of hepatocytes and marked ductular reaction around portal tracts. Acute lobular hepatitis with lesser degrees of necrosis and some regeneration forms nodules and mimics cirrhosis.
Clinical findings
Low-grade fever, anorexia, nausea, vomiting, fatigue, malaise, headache, photophobia, pharyngitis, cough; later, dark urine, light stool, jaundice, hepatomegaly, ±splenomegaly, ±lymphadenopathy.
Aetiology
Autoimmune, drugs, toxins, viral.

Lab
Decreased ALT falsely suggests liver improvement; raised prothrombin signals liver failure and need for tertiary (liver centre) referral.
Diagnosis
Liver biopsy; increased transaminases (ALT, AST); increased virus-specific IgG or IgM.

单词	acute lobular hepatitis
释义	acute lobular hepatitis acute lobular hepatitis Liver inflammation of abrupt onset, which is characterised by patchy confluent pan- and multi-acinar necrosis, with loss of hepatocytes and marked ductular reaction around portal tracts. Acute lobular hepatitis with lesser degrees of necrosis and some regeneration forms nodules and mimics cirrhosis. Clinical findings Low-grade fever, anorexia, nausea, vomiting, fatigue, malaise, headache, photophobia, pharyngitis, cough; later, dark urine, light stool, jaundice, hepatomegaly, ±splenomegaly, ±lymphadenopathy. Aetiology Autoimmune, drugs, toxins, viral. Lab Decreased ALT falsely suggests liver improvement; raised prothrombin signals liver failure and need for tertiary (liver centre) referral. Diagnosis Liver biopsy; increased transaminases (ALT, AST); increased virus-specific IgG or IgM.
随便看	laughing our asses off laughing out loud again laughing out loud and a half laughing out loud back at you laughing out loud, but crying on the inside laughing out loud for real laughing out loud, just kidding mldf mldg mldi ml (disambiguation) ml-dl mldl mldlp mldm mldn mldo mld-op mldp mldr mldrin mld-rs mlds mldsa mldse