galectin-3

A 30-kD protein, a beta-galactosidase-binding lectin encoded by LGALS3 on chromosome 14q22.3, which is thought to be involved in cell growth, adhesion, acute inflammation (neutrophil activation and adhesion, chemoattraction of macrophages, and activation of mast cells), mRNA splicing and processing, and apoptosis.
Normal expression
Mainly in the nucleus of epithelial and immune cells, neutrophils, and vascular endothelium.
Abnormal expression
Over-expression is linked to malignant transformation and metastases in carcinomas of the breast, colon, tongue, liver, and thyroid.

单词	galectin-3
释义	galectin-3 galectin-3 A 30-kD protein, a beta-galactosidase-binding lectin encoded by LGALS3 on chromosome 14q22.3, which is thought to be involved in cell growth, adhesion, acute inflammation (neutrophil activation and adhesion, chemoattraction of macrophages, and activation of mast cells), mRNA splicing and processing, and apoptosis. Normal expression Mainly in the nucleus of epithelial and immune cells, neutrophils, and vascular endothelium. Abnormal expression Over-expression is linked to malignant transformation and metastases in carcinomas of the breast, colon, tongue, liver, and thyroid.
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