genomic imprinting

epigenetic process that leads to inactivation of paternal or maternal allele of certain genes susceptible to epigenetic regulation; accounts, among others, for the Angelman and Prader-Willi syndromes.

ge·nom·ic im·print·ing

(jē-nō'mik im'print-ing) Epigenetic process that leads to inactivation of paternal or maternal allele of certain genes susceptible to epigenetic regulation; accounts, among others, for the Angelman and Prader-Willi syndromes.

genomic imprinting

The concept, derived from an increasing body of compelling evidence, that the expression of some of the genes depends on whether they have been derived from the father or from the mother. It has been shown, for instance, that chromosomal deletion in chromosomes of parental origin may differ in their effect from the same deletion in the homologous chromosome of maternal origin. Many cancers are associated with loss of a particular chromosome derived from a particular parent—usually the mother. The DNA of some genes is modified during the formation of gametes so as to have altered expression and be activated or inactivated.

genomic imprinting

the process whereby certain genes are modified (principally by METHYLATION) during GAMETOGENESIS, resulting in differential expression of parental alleles depending on whether of maternal or paternal origin. The ‘imprinted’ regions of the DNA are generally less active in transcription. Offspring normally inherit one maternal and one paternal copy of their genes, and generally both copies are active. However, expression of certain genes occurs from only one of the two copies, as a result of imprinting of either the maternal or paternal ALLELE at a particular LOCUS. The phenomenon can occur in a variety of organisms. Only a few human genes are imprinted and they tend to be clustered in the genome. Imprinting may have no effect on health and development, but in some cases can cause medical disorders such as Prader-Willi Syndrome and Angelman Syndrome. See also UNIPARENTAL DISOMY.

单词	genomic imprinting
释义	genomic imprinting genomic imprinting [jə¦nō·mik im‚print·iŋ] (genetics) parental imprinting genomic imprinting genomic imprinting epigenetic process that leads to inactivation of paternal or maternal allele of certain genes susceptible to epigenetic regulation; accounts, among others, for the Angelman and Prader-Willi syndromes. ge·nom·ic im·print·ing (jē-nō'mik im'print-ing) Epigenetic process that leads to inactivation of paternal or maternal allele of certain genes susceptible to epigenetic regulation; accounts, among others, for the Angelman and Prader-Willi syndromes. genomic imprinting The concept, derived from an increasing body of compelling evidence, that the expression of some of the genes depends on whether they have been derived from the father or from the mother. It has been shown, for instance, that chromosomal deletion in chromosomes of parental origin may differ in their effect from the same deletion in the homologous chromosome of maternal origin. Many cancers are associated with loss of a particular chromosome derived from a particular parent—usually the mother. The DNA of some genes is modified during the formation of gametes so as to have altered expression and be activated or inactivated. genomic imprinting the process whereby certain genes are modified (principally by METHYLATION) during GAMETOGENESIS, resulting in differential expression of parental alleles depending on whether of maternal or paternal origin. The ‘imprinted’ regions of the DNA are generally less active in transcription. Offspring normally inherit one maternal and one paternal copy of their genes, and generally both copies are active. However, expression of certain genes occurs from only one of the two copies, as a result of imprinting of either the maternal or paternal ALLELE at a particular LOCUS. The phenomenon can occur in a variety of organisms. Only a few human genes are imprinted and they tend to be clustered in the genome. Imprinting may have no effect on health and development, but in some cases can cause medical disorders such as Prader-Willi Syndrome and Angelman Syndrome. See also UNIPARENTAL DISOMY.
随便看	analog service unit analog shut off analog (signal) analog signal analog signal demodulator analog signal memory with intrinsic adjustment analog signal processing analog signals analog signal-to-distortion ratio analog simple data interface analog simultaneous voice and data analog single event transient analog sockets analog sound analog station card analog station interface analog stimulus and response unit analog stimulus response unit analog subscriber outlet analog sunset analog switch analog switching module analog switch-off analog symbol monitoring analog synthesizer