gonadoblastoma


go·nad·o·blas·to·ma

(gō-nad'ō-blas-tō'ma), [MIM*424500] Benign neoplasm composed of germ cells, sex cord derivatives, stromal cells; appears in cases of mixed or pure gonadal dysgenesis; usually small (1-3 cm) and partially calcified, but may give rise to malignant germ-cell tumors, most often seminoma/dysgerminoma or embryonal.

gonadoblastoma

Gynecology Dysgenetic gonadoma A mixed germ cell-sex cord-stromal tumor which is most commonly seen in sexually abnormal persons, especially with gonadal dysgenesis–GD with a Y chromosome–ie, XY GD and XO-XY mosaicism; gonadoblastomas carry a 25% risk of neoplasia. See Sex-cord tumor Urology A mixed germ cell-sex cord-stromal tumor which almost invariably arises in a background of a gonadal disorder, either pure or mixed gonadal dysgenesis, male pseudohermaphroditism or, less commonly, in a phenotypically or karyotypically normal male. See Sex cord-stromal tumor.

go·nad·o·blas·to·ma

(gō-nad'ō-blas-tō'ma) Rare, benign neoplasm composed of germ cells, sex cord derivatives, and stromal cells; appears in cases of mixed or pure gonadal dysgenesis; usually small (1-3 cm) and partially calcified but may give rise to malignant germ-cell tumors, most often seminoma and dysgerminoma or embryonal; usually bilateral; found in patients with gonadal dysgenesis.