| 单词 | fus | ||||||||||||||||||||
| 释义 | fusfusFUSFUSA gene on chromosome 16p11.2 that encodes a multifunctional protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, which is involved in pre-mRNA splicing and export of processed mRNA to the cytoplasm. FUS belongs to the FET family of RNA-binding proteins that regulate gene expression, maintain genomic integrity and process mRNA/microRNA processing.Molecular pathology FUS mutations cause amyotrophic lateral sclerosis type 6; a FUS/CHOP translocation (t(12;16)(q13;p11)) leads to the formation of a chimeric protein, which induces liposarcoma. FUS
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