gemfibrozil
gem·fi·bro·zil
G5075250 (jĕm-fī′brə-zĭl, -fĭb′rə-)gemfibrozil
(dʒɛmˈfaɪbrəʊzɪl)| Noun | 1. | gemfibrozil - medication (trade name Lopid) used to lower the levels of triglyceride in the blood |
gemfibrozil
gemfibrozil
[jem-fib´ro-zil]gemfibrozil
Pharmacologic class: Fibric acid derivative
Therapeutic class: Antihyperlipidemic
Pregnancy risk category C
Action
Inhibits peripheral lipolysis, resulting in decreased triglyceride levels. Also inhibits synthesis and increases clearance of very-low-density lipoproteins.
Availability
Tablets: 600 mg
Indications and dosages
➣ Type IIb hyperlipidemia in patients without coronary artery disease who don't respond to other treatments; adjunctive therapy for types IV and V hyperlipidemia
Adults: 1,200 mg P.O. daily in two divided doses
Contraindications
• Hypersensitivity to drug
• Gallbladder disease
• Severe renal dysfunction
• Hepatic dysfunction
Precautions
Use cautiously in:
• renal impairment, cholelithiasis, diabetes, hypothyroidism
• pregnant or breastfeeding patients
• children (safety not established).
Administration
• Give 30 minutes before a meal.
• Know that before starting drug and throughout therapy, patient should use dietary measures and exercise, as appropriate, to control hyperlipidemia.
Adverse reactions
CNS: fatigue, hypoesthesia, paresthesia, drowsiness, syncope, vertigo, dizziness, headache, seizures
CV: vasculitis
EENT: cataracts, blurred vision, retinal edema, hoarseness
GI: nausea, vomiting, diarrhea, abdominal or epigastric pain, heartburn, flatulence, gallstones, dry mouth
GU: dysuria, erectile dysfunction, decreased male fertility
Hematologic: eosinophilia, anemia, bone marrow hypoplasia, leukopenia, thrombocytopenia
Hepatic: hepatotoxicity
Metabolic: hypoglycemia
Musculoskeletal: joint, back, or muscle pain; myasthenia; myopathy; synovitis; myositis; rhabdomyolysis
Respiratory: cough
Skin: alopecia, rash, urticaria, eczema, pruritus, angioedema
Other: abnormal taste, chills, weight loss, increased risk of bacterial and viral infection, lupuslike syndrome, anaphylaxis
Interactions
Drug-drug. Chenodiol, ursodiol: decreased gemfibrozil efficacy
Cyclosporine: decreased cyclosporine effects
HMG-CoA reductase inhibitors: increased risk of rhabdomyolysis
Sulfonylureas: increased hypoglycemic effects
Warfarin: increased bleeding risk
Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, creatine kinase (CK), glucose, lactate dehydrogenase: increased values
Hematocrit, hemoglobin, potassium, white blood cells: decreased values
Patient monitoring
• Monitor kidney and liver function test results and serum lipid levels.
See Watch for signs and symptoms of adverse reactions, especially bleeding tendency and hypersensitivity reaction.
• Monitor periodic blood counts during first year of therapy.
• Check CK level if myopathy occurs.
Patient teaching
• Tell patient to take drug 30 minutes before breakfast and dinner.
See Advise patient to immediately report signs or symptoms of anaphylaxis (such as difficulty breathing or rash) or other allergic reactions.
See Instruct patient to immediately report unusual bleeding or bruising or muscle pain.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Stress importance of diet and exercise in lowering lipid levels.
• Inform patient that he'll undergo regular blood testing during therapy.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.
gemfibrozil
(jĕm-fī′brə-zĭl, -fĭb′rə-)gemfibrozil
Lopid® Cardiovascular disease A drug that inhibits VLDL synthesis, which ↓ M&M due to CAD, nonfatal MIs and strokes, by ↑ HDL-C and ↓ TGs. See Cholesterol-lowering drugs, Lovastatin, VA-HIT.gemfibrozil
A FIBRATE cholesterol-lowering drug. A brand name is Lopid.gemfibrozil
- noun
Synonyms for gemfibrozil
noun medication (trade name Lopid) used to lower the levels of triglyceride in the blood
Synonyms
- Lopid
Related Words
- medicament
- medication
- medicinal drug
- medicine