| 释义 |
FRS2
FRS2 A gene on chromosome 12q15 that encodes an adapter protein which links activated FGR and NGF receptors to downstream signalling pathways. FRS2 plays a key role in activating MAP kinases and in phosphorylating PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. FRS2 modulates signalling via SHC1 by competing with it for a common binding site on NTRK1. It is usually part of heteromultimeric protein complexes, and it is highly expressed in the heart, brain, spleen, lungs, liver, skeletal muscle, kidneys and testes.FRS2
| Acronym | Definition |
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| FRS2➣Factor Receptor Substrate 2 (gene) | | FRS2➣FGF (Fibroblast Growth Factor) Receptor Substrate 2 (protein) |
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