Definition of probenecid in English:
probenecid
noun prəʊˈbɛnɪsɪdprōˈbenəsəd
mass nounMedicine A synthetic sulphur-containing compound which promotes increased excretion of uric acid and is used to treat gout.
Example sentencesExamples
- Administration of this drug with probenecid should be avoided as it has been found to inhibit the renal excretion of meropenem.
- To decrease the potential for nephrotoxicity, coadministration of probenecid and hydration with 0.9% sodium chloride is required.
- There are two classes of drugs to reduce uric acid: uricosurics, such as probenecid, which increases excretion, and xanthine oxidase inhibitors, such as allopurinol, which reduce production.
- Scientists found that a simple benzoic acid derivative called probenecid stops many drugs, including antibiotics, being removed from the blood by the kidneys.
- Parenteral treatment refused: amoxycillin 500 mg four times a day plus probenecid 500 mg four times a day for 14 days
Origin
1950s: from pro(pyl) + ben(zoic) + -e- + (a)cid.