Definition of proinsulin in English:
proinsulin
nounprəʊˈɪnsjʊlɪnprōˈinsələn
mass nounBiochemistry A substance produced by the pancreas which is converted to insulin.
Example sentencesExamples
- The processing of proinsulin to insulin within the secretory granules of the Golgi complex is dependent on critical levels of pH as well as ATP.
- Following cleavage of the 24 amino acid signal peptide the protein folds into proinsulin.
- Insulin is synthesized as a precursor, preproinsulin, and after removal of the signal peptide, proinsulin folds to form the correct tertiary structure.
- Unlike the single chain precursor of insulin, proinsulin, this new construct retains up to 40 per cent of insulin activity.
- Insulin-like growth factor 1 is a peptide structurally related to proinsulin and has a primary role in promoting skeletal muscle differentiation and growth.