Definition of pleiotropy in English:

pleiotropy

noun plʌɪˈɒtrəpiplīˈätrəpē

mass nounGenetics

The production by a single gene of two or more apparently unrelated effects.
Example sentencesExamples
- These salutary effects of ezetimibe on statin levels presumably enhance the beneficial effects attributed to statin pleiotropy.
- At the level of populations, the scaling of mutational effects with pleiotropy can be addressed via the neutral theory of molecular evolution.
- If gene effects on the trait and fitness are correlated due to pleiotropy, genes of large effect on the trait will remain at much lower frequencies.
- These studies demonstrated that performance and preference of host-plant use may be genetically associated by linkage or pleiotropy, and evolve as correlated traits.
- In this study, three factors affecting the distribution of fixed mutational effects are evaluated: pleiotropy, drift, and stabilizing selection.

Derivatives

pleiotropic

adjective plʌɪəˈtrɒpɪkplʌɪəˈtrəʊpɪk

Genetics

Similarly, mutations within the Drosophila CBP homolog have wide-ranging pleiotropic phenotypes.
Example sentencesExamples
- There appears to be a common logic that can be discerned behind the list of these pleiotropic changes in cell metabolism.
- Conservation of this function in humans may explain many of the pleiotropic phenotypes of cartilage hair hypoplasia.
- Many mutants died or showed pleiotropic defects casting doubt on the specificity of their retinal phenotype and were not included in this report.
- Many semidwarf mutants have pleiotropic effects on traits other than culm length.

pleiotropism

noun

Genetics

Pleiotropism is a hallmark of cytokines and growth factors; yet, the underlying mechanisms are not clearly understood.
Example sentencesExamples
- The gene exhibited pleiotropism by influencing not only oleate and linoleate, but also levels of palmitate, gadoleate, and total saturated fatty acids.
- If the majority of mutations have large negative impacts on fitness, pleiotropism will act to increase their selective effects in nature.

Origin

1930s: from Greek pleiōn 'more' + tropē 'turning'.

Definition of pleiotropy in US English:

pleiotropy

nounplīˈätrəpē

Genetics

The production by a single gene of two or more apparently unrelated effects.
Example sentencesExamples
- These studies demonstrated that performance and preference of host-plant use may be genetically associated by linkage or pleiotropy, and evolve as correlated traits.
- These salutary effects of ezetimibe on statin levels presumably enhance the beneficial effects attributed to statin pleiotropy.
- In this study, three factors affecting the distribution of fixed mutational effects are evaluated: pleiotropy, drift, and stabilizing selection.
- If gene effects on the trait and fitness are correlated due to pleiotropy, genes of large effect on the trait will remain at much lower frequencies.
- At the level of populations, the scaling of mutational effects with pleiotropy can be addressed via the neutral theory of molecular evolution.

Origin

1930s: from Greek pleiōn ‘more’ + tropē ‘turning’.

单词	pleiotropy
释义	Definition of pleiotropy in English: pleiotropy noun plʌɪˈɒtrəpiplīˈätrəpē mass nounGenetics The production by a single gene of two or more apparently unrelated effects. Example sentencesExamples These salutary effects of ezetimibe on statin levels presumably enhance the beneficial effects attributed to statin pleiotropy. At the level of populations, the scaling of mutational effects with pleiotropy can be addressed via the neutral theory of molecular evolution. If gene effects on the trait and fitness are correlated due to pleiotropy, genes of large effect on the trait will remain at much lower frequencies. These studies demonstrated that performance and preference of host-plant use may be genetically associated by linkage or pleiotropy, and evolve as correlated traits. In this study, three factors affecting the distribution of fixed mutational effects are evaluated: pleiotropy, drift, and stabilizing selection. Derivatives pleiotropic adjective plʌɪəˈtrɒpɪkplʌɪəˈtrəʊpɪk Genetics Similarly, mutations within the Drosophila CBP homolog have wide-ranging pleiotropic phenotypes. Example sentencesExamples There appears to be a common logic that can be discerned behind the list of these pleiotropic changes in cell metabolism. Conservation of this function in humans may explain many of the pleiotropic phenotypes of cartilage hair hypoplasia. Many mutants died or showed pleiotropic defects casting doubt on the specificity of their retinal phenotype and were not included in this report. Many semidwarf mutants have pleiotropic effects on traits other than culm length. pleiotropism noun Genetics Pleiotropism is a hallmark of cytokines and growth factors; yet, the underlying mechanisms are not clearly understood. Example sentencesExamples The gene exhibited pleiotropism by influencing not only oleate and linoleate, but also levels of palmitate, gadoleate, and total saturated fatty acids. If the majority of mutations have large negative impacts on fitness, pleiotropism will act to increase their selective effects in nature. Origin 1930s: from Greek pleiōn 'more' + tropē 'turning'. Definition of pleiotropy in US English: pleiotropy nounplīˈätrəpē Genetics The production by a single gene of two or more apparently unrelated effects. Example sentencesExamples These studies demonstrated that performance and preference of host-plant use may be genetically associated by linkage or pleiotropy, and evolve as correlated traits. These salutary effects of ezetimibe on statin levels presumably enhance the beneficial effects attributed to statin pleiotropy. In this study, three factors affecting the distribution of fixed mutational effects are evaluated: pleiotropy, drift, and stabilizing selection. If gene effects on the trait and fitness are correlated due to pleiotropy, genes of large effect on the trait will remain at much lower frequencies. At the level of populations, the scaling of mutational effects with pleiotropy can be addressed via the neutral theory of molecular evolution. Origin 1930s: from Greek pleiōn ‘more’ + tropē ‘turning’.
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