Definition of leukotriene in English:
leukotriene
noun ˌluːkə(ʊ)ˈtrʌɪiːnˌlo͞okəˈtrīēn
Biochemistry Any of a group of biologically active compounds, originally isolated from leucocytes. They are metabolites of arachidonic acid, containing three conjugated double bonds.
Example sentencesExamples
- In addition to chemokines, lipid metabolites such as leukotrienes and prostaglandins are emerging as important upstream controllers of DC migration toward LNs.
- Arachidonic acid metabolites such as leukotrienes and thromboxanes have been shown to increase in the lung during ischemia-reperfusion injury in a dog model of warm ischemia.
- Prostaglandins and leukotrienes from arachidonic acid metabolism are highly inflammatory molecules, and play an important role in the pathophysiology of asthma.
- During the early phase, mast cells release mediators (e.g., histamine, leukotrienes, prostaglandins and thromboxanes) that lead to vasodilation, edema and bronchoconstriction.
- These breakdown products can become toxic to the membrane due to excess levels of free radicals, lipid peroxides, and arachidonic acid and its metabolites such as leukotrienes.