Definition of transdifferentiation in US English:
transdifferentiation
noun tranzˌdifəˌrenSHēˈāSHəntranzˌdifəˌrenSHēˈāSHən
Biology The rare natural transformation of cells other than stem cells into a different cell type.
Example sentencesExamples
- Further scrutiny has also thrown cold water on many of the transdifferentiation claims for other types of adult stem cells.
- Histology, immunohistochemistry, and ultrastructure were highly suggestive of transdifferentiation from cardiac muscle to adipose tissue.
- We favor cytokine-and growth factor-dependent transdifferentiation of resident fibroblasts into myofibroblasts.
- Another possibility is to replace the missing function by causing transdifferentiation of existing cells.
- A particularly interesting example of transdifferentiation, in which one cell type transdifferentiates into two different types in succession, is provided by jellyfish striated muscle.
Derivatives
verb -SHēˌāt
Biology When we over-expressed Math1 in non-sensory cells of the mature cochlea, however, we found that it causes them to transdifferentiate or change their personality to become hair cells.
Example sentencesExamples
- A particularly interesting example of transdifferentiation, in which one cell type transdifferentiates into two different types in succession, is provided by jellyfish striated muscle.
- This plasticity concept - the ability of bone marrow cell to transdifferentiate into heart muscle cell - is supported by experimental and clinical data.
- ‘We thought if we can find the master-switch gene for pancreas and somehow deliver it to liver cells, we could transdifferentiate liver into pancreas,’ he explains.
- Primordial germ cells that have been labeled using horseradish peroxidase or radioactive thymidine do not transdifferentiate, and very few transplanted cells persist outside of the gonads.
Definition of transdifferentiation in US English:
transdifferentiation
nountranzˌdifəˌrenSHēˈāSHən
Biology The rare natural transformation of cells other than stem cells into a different cell type.
Example sentencesExamples
- Further scrutiny has also thrown cold water on many of the transdifferentiation claims for other types of adult stem cells.
- We favor cytokine-and growth factor-dependent transdifferentiation of resident fibroblasts into myofibroblasts.
- A particularly interesting example of transdifferentiation, in which one cell type transdifferentiates into two different types in succession, is provided by jellyfish striated muscle.
- Histology, immunohistochemistry, and ultrastructure were highly suggestive of transdifferentiation from cardiac muscle to adipose tissue.
- Another possibility is to replace the missing function by causing transdifferentiation of existing cells.