Definition of tophus in English:

tophus

nounPlural tophi ˈtəʊfəsˈtoʊfəs

Medicine

A deposit of crystalline uric acid and other substances at the surface of joints or in skin or cartilage, typically as a feature of gout.
Example sentencesExamples
- Only a minority of patients with hyperuricemia develops tophi and gouty arthritis.
- Crystal deposits may also build up under the skin around the joints and behind the ears, causing small lumps known as tophi and, in a few cases, in the kidneys.
- Diagnosis is by removing fluid from an affected joint or tophus and identifying urate crystals under a polarized-light microscope.
- Definite diagnosis can be made by demonstration of the presence of monosodium urate crystals within synovial leukocytes or in material derived from tophi under polarizing microscopy.
- The slides stained with HE and our method were examined with a light microscope for the presence of urate crystals and diagnostic histologic features of gouty tophus.
- Four years later, he obtained uric acid from a gouty tophus.
- Patients with long-standing gout may have tophi over the olecranon prominence, first metatarsal joints, or pinnae.
- Joint damage in hyperuricemia causes classical attacks of gout but tophi may also develop in cartilage, tendons and other tissues.
- If histopathology of a tophus or synovial biopsy suggests gout, fine-needle aspiration may be an alternative for crystal identification and subsequent definitive diagnosis.
- Less commonly, a septic arthritis of the knee or the big toe can occur in association with gout, particularly when a tophus has ulcerated and become secondarily infected.
- Chalky deposits called tophi may appear under the skin around joints and in the cartilage of the ears.
- One swallow does not make a summer, but one tophus makes gout and one crescent malaria.

Origin

Early 17th century: from Latin, denoting loose porous stones of various kinds.

Definition of tophus in US English:

tophus

nounˈtōfəsˈtoʊfəs

Medicine

A deposit of crystalline uric acid and other substances at the surface of joints or in skin or cartilage, typically as a feature of gout.
Example sentencesExamples
- Joint damage in hyperuricemia causes classical attacks of gout but tophi may also develop in cartilage, tendons and other tissues.
- Definite diagnosis can be made by demonstration of the presence of monosodium urate crystals within synovial leukocytes or in material derived from tophi under polarizing microscopy.
- One swallow does not make a summer, but one tophus makes gout and one crescent malaria.
- Four years later, he obtained uric acid from a gouty tophus.
- If histopathology of a tophus or synovial biopsy suggests gout, fine-needle aspiration may be an alternative for crystal identification and subsequent definitive diagnosis.
- Only a minority of patients with hyperuricemia develops tophi and gouty arthritis.
- Diagnosis is by removing fluid from an affected joint or tophus and identifying urate crystals under a polarized-light microscope.
- Patients with long-standing gout may have tophi over the olecranon prominence, first metatarsal joints, or pinnae.
- Chalky deposits called tophi may appear under the skin around joints and in the cartilage of the ears.
- Crystal deposits may also build up under the skin around the joints and behind the ears, causing small lumps known as tophi and, in a few cases, in the kidneys.
- Less commonly, a septic arthritis of the knee or the big toe can occur in association with gout, particularly when a tophus has ulcerated and become secondarily infected.
- The slides stained with HE and our method were examined with a light microscope for the presence of urate crystals and diagnostic histologic features of gouty tophus.

Origin

Early 17th century: from Latin, denoting loose porous stones of various kinds.

单词	tophus
释义	Definition of tophus in English: tophus nounPlural tophi ˈtəʊfəsˈtoʊfəs Medicine A deposit of crystalline uric acid and other substances at the surface of joints or in skin or cartilage, typically as a feature of gout. Example sentencesExamples Only a minority of patients with hyperuricemia develops tophi and gouty arthritis. Crystal deposits may also build up under the skin around the joints and behind the ears, causing small lumps known as tophi and, in a few cases, in the kidneys. Diagnosis is by removing fluid from an affected joint or tophus and identifying urate crystals under a polarized-light microscope. Definite diagnosis can be made by demonstration of the presence of monosodium urate crystals within synovial leukocytes or in material derived from tophi under polarizing microscopy. The slides stained with HE and our method were examined with a light microscope for the presence of urate crystals and diagnostic histologic features of gouty tophus. Four years later, he obtained uric acid from a gouty tophus. Patients with long-standing gout may have tophi over the olecranon prominence, first metatarsal joints, or pinnae. Joint damage in hyperuricemia causes classical attacks of gout but tophi may also develop in cartilage, tendons and other tissues. If histopathology of a tophus or synovial biopsy suggests gout, fine-needle aspiration may be an alternative for crystal identification and subsequent definitive diagnosis. Less commonly, a septic arthritis of the knee or the big toe can occur in association with gout, particularly when a tophus has ulcerated and become secondarily infected. Chalky deposits called tophi may appear under the skin around joints and in the cartilage of the ears. One swallow does not make a summer, but one tophus makes gout and one crescent malaria. Origin Early 17th century: from Latin, denoting loose porous stones of various kinds. Definition of tophus in US English: tophus nounˈtōfəsˈtoʊfəs Medicine A deposit of crystalline uric acid and other substances at the surface of joints or in skin or cartilage, typically as a feature of gout. Example sentencesExamples Joint damage in hyperuricemia causes classical attacks of gout but tophi may also develop in cartilage, tendons and other tissues. Definite diagnosis can be made by demonstration of the presence of monosodium urate crystals within synovial leukocytes or in material derived from tophi under polarizing microscopy. One swallow does not make a summer, but one tophus makes gout and one crescent malaria. Four years later, he obtained uric acid from a gouty tophus. If histopathology of a tophus or synovial biopsy suggests gout, fine-needle aspiration may be an alternative for crystal identification and subsequent definitive diagnosis. Only a minority of patients with hyperuricemia develops tophi and gouty arthritis. Diagnosis is by removing fluid from an affected joint or tophus and identifying urate crystals under a polarized-light microscope. Patients with long-standing gout may have tophi over the olecranon prominence, first metatarsal joints, or pinnae. Chalky deposits called tophi may appear under the skin around joints and in the cartilage of the ears. Crystal deposits may also build up under the skin around the joints and behind the ears, causing small lumps known as tophi and, in a few cases, in the kidneys. Less commonly, a septic arthritis of the knee or the big toe can occur in association with gout, particularly when a tophus has ulcerated and become secondarily infected. The slides stained with HE and our method were examined with a light microscope for the presence of urate crystals and diagnostic histologic features of gouty tophus. Origin Early 17th century: from Latin, denoting loose porous stones of various kinds.
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