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单词 topoisomer
释义

Definition of topoisomer in English:

topoisomer

nounˌtɒpəʊˈʌɪsəməˌtäpōˈīsəmər
Biochemistry
  • A topologically distinct isomer, especially of DNA.

    Example sentencesExamples
    • An extract was deemed to be deficient if, in all three trials, the ratio of intermediate to supercoiled products indicated an accumulation of intermediate topoisomers (compared to wild type).
    • The distribution of 2 plasmid DNA topoisomers was measured by Southern blot analysis with a radiolabeled 2 DNA probe.
    • Comparing the topoisomer distribution of plasmid DNA from the ancestor with the completely relaxed plasmid control yielded an estimate of = - 0.066 for the ancestor.
    • This suggests that the main contribution to the variation in adjusted parameters comes from the presence of a distribution in topoisomers rather than thermal fluctuations.
    • The 9C 14 loop was observed to give a mixture of a relaxed topoisomer, a positive supercoil, and a small amount of negative supercoil upon ring closure, whereas 11C12 gave mainly a relaxed topoisomer.
    • In the sequence used here, the presence of L-Gln residues may lead to topoisomers.
 
 

Definition of topoisomer in US English:

topoisomer

nounˌtäpōˈīsəmər
Biochemistry
  • A topologically distinct isomer, especially of DNA.

    Example sentencesExamples
    • The distribution of 2 plasmid DNA topoisomers was measured by Southern blot analysis with a radiolabeled 2 DNA probe.
    • An extract was deemed to be deficient if, in all three trials, the ratio of intermediate to supercoiled products indicated an accumulation of intermediate topoisomers (compared to wild type).
    • The 9C 14 loop was observed to give a mixture of a relaxed topoisomer, a positive supercoil, and a small amount of negative supercoil upon ring closure, whereas 11C12 gave mainly a relaxed topoisomer.
    • This suggests that the main contribution to the variation in adjusted parameters comes from the presence of a distribution in topoisomers rather than thermal fluctuations.
    • Comparing the topoisomer distribution of plasmid DNA from the ancestor with the completely relaxed plasmid control yielded an estimate of = - 0.066 for the ancestor.
    • In the sequence used here, the presence of L-Gln residues may lead to topoisomers.
 
 
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更新时间:2025/1/11 7:31:05