Definition of vinblastine in English:

vinblastine

noun vɪnˈblastiːnvinˈblasˌtēn

mass nounMedicine

A cytotoxic compound of the alkaloid class obtained from the Madagascar periwinkle and used to treat Hodgkin's disease and other cancers of the lymphatic system.
Example sentencesExamples
- Past bioprospected compounds that received FDA approval include taxol, topotecan, vinblastine, vincristine, and irinocetan.
- Treatment arm 2, which consisted of cisplatin and vinblastine before irradiation, required that irradiation began on day 50.
- The patient was a 33-year-old man with a history of nodular sclerosis Hodgkin disease after 2 cycles of doxorubicin hydrochloride, bleomycin sulfate, vinblastine sulfate, and dacarbazine.
- The most frequently used drugs were cyclophosphamide, vincristine, vinblastine, cis-platinum, 5-fluorouracil, bleomycin, methotrexate and adriamycin.
- Due to the bulky nature of the disease, all the patients had received a course of chemotherapy with doxorubicin, bleomycin, vinblastine, and dacarbazine, and they were scheduled for MRT.
- Some types of medications used include azathioprine, vincristine, cyclophosphamide, cyclosporine or vinblastine.
- A 49 year old man with transitional cell carcinoma of the bladder received chemotherapy with cisplatin, methotrexate, and vinblastine after resection of a tumour.
- Other groups also have reported good results with mitomycin, vinblastine, and cisplatin, although the regimen produced excessive toxicity in some series.
- For example, the drugs vinblastine and vincristine - which come from the periwinkle plant - are used to treat many different cancers.
- Tubulin binds also different drugs such as colchicine, vinblastine, podophyllotoxin, which inhibit tubulin assembly or depolymerize existing microtubules at micromolar concentrations.
- The patient was then given one cycle of salvage chemotherapy consisting of vinblastine, ifosfamide, and cisplatin without any response.
- What do aspirin, codeine, ipecac, reserpine, scopolamine, theophylline, and vinblastine have in common?
- The sensitivity to vindesine and vinblastine in the drug-sensitive cell line increased about two-fold in the presence of GLA.
- The most notable side-effects of vincristine and vinblastine are neurotoxic and myelosuppressive; influencing motor and neuron function, along with bone marrow depression.
- Of the plant-derived anticancer drugs in clinical use, the best known are the alkaloids vinblastine and vincristine, isolated from the Madagascar periwinkle, Catharanthus roseus.
- After surgery, the patient received 4 cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine).
- Reports have documented postcoital allergic reactions including asthma in female subjects due to ingestion of walnut, vinblastine, thioridazine, and penicillin by the male partner before coitus.
- In this study the spindle poison vinblastine was used as a model compound to assess the influence of donor age on chemically induced chromosome malsegregation in cultured lymphocytes.
- We studied the effects of the chemicals acrylamide, colchicine, diazepam, griseofulvin, taxol, thiobendazole, trichlorfon and vinblastine on the duration of meiotic divisions in male mice.
- Treatment for stage IVB Hodgkin lymphoma was begun, consisting of cytoxan, oncovin, prednisone, and procarbazine alternating with adriamycin, bleomycin, and vinblastine.

Origin

1960s: from modern Latin Vinca (see vinca) + (leuco)blast (a cell from which a leucocyte develops) + -ine⁴.

Definition of vinblastine in US English:

vinblastine

nounvinˈblasˌtēn

Medicine

A cytotoxic compound of the alkaloid class obtained from the Madagascar periwinkle and used to treat Hodgkin's disease and other cancers of the lymphatic system.
Example sentencesExamples
- Other groups also have reported good results with mitomycin, vinblastine, and cisplatin, although the regimen produced excessive toxicity in some series.
- Treatment for stage IVB Hodgkin lymphoma was begun, consisting of cytoxan, oncovin, prednisone, and procarbazine alternating with adriamycin, bleomycin, and vinblastine.
- Treatment arm 2, which consisted of cisplatin and vinblastine before irradiation, required that irradiation began on day 50.
- The patient was a 33-year-old man with a history of nodular sclerosis Hodgkin disease after 2 cycles of doxorubicin hydrochloride, bleomycin sulfate, vinblastine sulfate, and dacarbazine.
- Some types of medications used include azathioprine, vincristine, cyclophosphamide, cyclosporine or vinblastine.
- The most notable side-effects of vincristine and vinblastine are neurotoxic and myelosuppressive; influencing motor and neuron function, along with bone marrow depression.
- In this study the spindle poison vinblastine was used as a model compound to assess the influence of donor age on chemically induced chromosome malsegregation in cultured lymphocytes.
- Past bioprospected compounds that received FDA approval include taxol, topotecan, vinblastine, vincristine, and irinocetan.
- A 49 year old man with transitional cell carcinoma of the bladder received chemotherapy with cisplatin, methotrexate, and vinblastine after resection of a tumour.
- Reports have documented postcoital allergic reactions including asthma in female subjects due to ingestion of walnut, vinblastine, thioridazine, and penicillin by the male partner before coitus.
- Of the plant-derived anticancer drugs in clinical use, the best known are the alkaloids vinblastine and vincristine, isolated from the Madagascar periwinkle, Catharanthus roseus.
- We studied the effects of the chemicals acrylamide, colchicine, diazepam, griseofulvin, taxol, thiobendazole, trichlorfon and vinblastine on the duration of meiotic divisions in male mice.
- What do aspirin, codeine, ipecac, reserpine, scopolamine, theophylline, and vinblastine have in common?
- The most frequently used drugs were cyclophosphamide, vincristine, vinblastine, cis-platinum, 5-fluorouracil, bleomycin, methotrexate and adriamycin.
- Tubulin binds also different drugs such as colchicine, vinblastine, podophyllotoxin, which inhibit tubulin assembly or depolymerize existing microtubules at micromolar concentrations.
- For example, the drugs vinblastine and vincristine - which come from the periwinkle plant - are used to treat many different cancers.
- Due to the bulky nature of the disease, all the patients had received a course of chemotherapy with doxorubicin, bleomycin, vinblastine, and dacarbazine, and they were scheduled for MRT.
- The patient was then given one cycle of salvage chemotherapy consisting of vinblastine, ifosfamide, and cisplatin without any response.
- The sensitivity to vindesine and vinblastine in the drug-sensitive cell line increased about two-fold in the presence of GLA.
- After surgery, the patient received 4 cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine).

Origin

1960s: from modern Latin Vinca (see vinca) + (leuco)blast (a cell from which a leucocyte develops) + -ine.

单词	vinblastine
释义	Definition of vinblastine in English: vinblastine noun vɪnˈblastiːnvinˈblasˌtēn mass nounMedicine A cytotoxic compound of the alkaloid class obtained from the Madagascar periwinkle and used to treat Hodgkin's disease and other cancers of the lymphatic system. Example sentencesExamples Past bioprospected compounds that received FDA approval include taxol, topotecan, vinblastine, vincristine, and irinocetan. Treatment arm 2, which consisted of cisplatin and vinblastine before irradiation, required that irradiation began on day 50. The patient was a 33-year-old man with a history of nodular sclerosis Hodgkin disease after 2 cycles of doxorubicin hydrochloride, bleomycin sulfate, vinblastine sulfate, and dacarbazine. The most frequently used drugs were cyclophosphamide, vincristine, vinblastine, cis-platinum, 5-fluorouracil, bleomycin, methotrexate and adriamycin. Due to the bulky nature of the disease, all the patients had received a course of chemotherapy with doxorubicin, bleomycin, vinblastine, and dacarbazine, and they were scheduled for MRT. Some types of medications used include azathioprine, vincristine, cyclophosphamide, cyclosporine or vinblastine. A 49 year old man with transitional cell carcinoma of the bladder received chemotherapy with cisplatin, methotrexate, and vinblastine after resection of a tumour. Other groups also have reported good results with mitomycin, vinblastine, and cisplatin, although the regimen produced excessive toxicity in some series. For example, the drugs vinblastine and vincristine - which come from the periwinkle plant - are used to treat many different cancers. Tubulin binds also different drugs such as colchicine, vinblastine, podophyllotoxin, which inhibit tubulin assembly or depolymerize existing microtubules at micromolar concentrations. The patient was then given one cycle of salvage chemotherapy consisting of vinblastine, ifosfamide, and cisplatin without any response. What do aspirin, codeine, ipecac, reserpine, scopolamine, theophylline, and vinblastine have in common? The sensitivity to vindesine and vinblastine in the drug-sensitive cell line increased about two-fold in the presence of GLA. The most notable side-effects of vincristine and vinblastine are neurotoxic and myelosuppressive; influencing motor and neuron function, along with bone marrow depression. Of the plant-derived anticancer drugs in clinical use, the best known are the alkaloids vinblastine and vincristine, isolated from the Madagascar periwinkle, Catharanthus roseus. After surgery, the patient received 4 cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine). Reports have documented postcoital allergic reactions including asthma in female subjects due to ingestion of walnut, vinblastine, thioridazine, and penicillin by the male partner before coitus. In this study the spindle poison vinblastine was used as a model compound to assess the influence of donor age on chemically induced chromosome malsegregation in cultured lymphocytes. We studied the effects of the chemicals acrylamide, colchicine, diazepam, griseofulvin, taxol, thiobendazole, trichlorfon and vinblastine on the duration of meiotic divisions in male mice. Treatment for stage IVB Hodgkin lymphoma was begun, consisting of cytoxan, oncovin, prednisone, and procarbazine alternating with adriamycin, bleomycin, and vinblastine. Origin 1960s: from modern Latin Vinca (see vinca) + (leuco)blast (a cell from which a leucocyte develops) + -ine⁴. Definition of vinblastine in US English: vinblastine nounvinˈblasˌtēn Medicine A cytotoxic compound of the alkaloid class obtained from the Madagascar periwinkle and used to treat Hodgkin's disease and other cancers of the lymphatic system. Example sentencesExamples Other groups also have reported good results with mitomycin, vinblastine, and cisplatin, although the regimen produced excessive toxicity in some series. Treatment for stage IVB Hodgkin lymphoma was begun, consisting of cytoxan, oncovin, prednisone, and procarbazine alternating with adriamycin, bleomycin, and vinblastine. Treatment arm 2, which consisted of cisplatin and vinblastine before irradiation, required that irradiation began on day 50. The patient was a 33-year-old man with a history of nodular sclerosis Hodgkin disease after 2 cycles of doxorubicin hydrochloride, bleomycin sulfate, vinblastine sulfate, and dacarbazine. Some types of medications used include azathioprine, vincristine, cyclophosphamide, cyclosporine or vinblastine. The most notable side-effects of vincristine and vinblastine are neurotoxic and myelosuppressive; influencing motor and neuron function, along with bone marrow depression. In this study the spindle poison vinblastine was used as a model compound to assess the influence of donor age on chemically induced chromosome malsegregation in cultured lymphocytes. Past bioprospected compounds that received FDA approval include taxol, topotecan, vinblastine, vincristine, and irinocetan. A 49 year old man with transitional cell carcinoma of the bladder received chemotherapy with cisplatin, methotrexate, and vinblastine after resection of a tumour. Reports have documented postcoital allergic reactions including asthma in female subjects due to ingestion of walnut, vinblastine, thioridazine, and penicillin by the male partner before coitus. Of the plant-derived anticancer drugs in clinical use, the best known are the alkaloids vinblastine and vincristine, isolated from the Madagascar periwinkle, Catharanthus roseus. We studied the effects of the chemicals acrylamide, colchicine, diazepam, griseofulvin, taxol, thiobendazole, trichlorfon and vinblastine on the duration of meiotic divisions in male mice. What do aspirin, codeine, ipecac, reserpine, scopolamine, theophylline, and vinblastine have in common? The most frequently used drugs were cyclophosphamide, vincristine, vinblastine, cis-platinum, 5-fluorouracil, bleomycin, methotrexate and adriamycin. Tubulin binds also different drugs such as colchicine, vinblastine, podophyllotoxin, which inhibit tubulin assembly or depolymerize existing microtubules at micromolar concentrations. For example, the drugs vinblastine and vincristine - which come from the periwinkle plant - are used to treat many different cancers. Due to the bulky nature of the disease, all the patients had received a course of chemotherapy with doxorubicin, bleomycin, vinblastine, and dacarbazine, and they were scheduled for MRT. The patient was then given one cycle of salvage chemotherapy consisting of vinblastine, ifosfamide, and cisplatin without any response. The sensitivity to vindesine and vinblastine in the drug-sensitive cell line increased about two-fold in the presence of GLA. After surgery, the patient received 4 cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine). Origin 1960s: from modern Latin Vinca (see vinca) + (leuco)blast (a cell from which a leucocyte develops) + -ine.
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