单词	provirus
释义	provirus /prəʊˈvʌɪrəs / noun Microbiology The genetic material of a virus as incorporated into, and able to replicate with, the genome of a host cell.HERV-W proviruses probably entered the genome of primates before the split between Old World and New World monkeys.... Recombination requires the simultaneous infection of a cell with two different proviruses, allowing the encapsulation of one RNA transcript from each provirus into a heterozygous virion. Once integrated with the host's genetic material, the DNA version of the retroviral RNA is called a provirus. Derivatives proviral adjective ... Identification of clonal proviral insertions by oncogenic retroviruses has led to the isolation of novel tumor-associated genes. It is generally admitted that these Human Endogenous RetroViruses derive originally from rare events of germ-line infections by exogenous retroviruses leading to proviral DNA integration. To identify expressed sequences, 16 kb of genomic DNA flanking the proviral integration site was sequenced and compared to genetic databases.
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