worn out, exhausted, fatigued, tired, tired out, weary, wearied, strained, drained, worn, sapped, spent, washed out, on one's last legs

informal worn to a frazzle, done, all in, dog-tired, dead on one's feet, dead beat, fit to drop, played out, fagged out, shattered, bushed

British informal knackered, whacked

North American informal pooped, tuckered out