单词	topoisomerase
释义	topoisomerase /ˌtɒpəʊˈʌɪsəməreɪz / noun Biochemistry An enzyme which alters the supercoiled form of a DNA molecule.Taken together, these results indicate that the overexpression of the topoisomerase I gene causes DNA damage that is lethal only in the scaA - background.... Among the genes affected by supercoiling are the topoisomerase genes. The clastogenicity of topoisomerase inhibitors is believed to result from the transient stabilization of the topoisomerase enzyme with DNA during the catalytic cycle. Origin 1970s: from Greek topos 'place' + isomer + -ase.
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