Albright's hereditary osteodystrophy
(also Albright hereditary osteodystrophy) Medicine
noun
A familial type of pseudohypoparathyroidism characterized by resistance to parathyroid hormone and by physical abnormalities including short stature, round face, short metacarpal and metatarsal bones, and the presence of subcutaneous ectopic calcifications.
- This type of pseudohypoparathyroidism results from mutations in a gene coding for a guanine nucleotide binding protein; pseudopseudohypoparathyroidism is now thought to be an incomplete form of the same disorder in persons inheriting the abnormal gene from the father rather than the mother (as a result of genomic imprinting)..
Origin
1960s; earliest use found in Annals of Internal Medicine.
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