phorbol
/ˈfɔːbɒl
/noun [mass noun] Chemistry
A compound present (in the form of highly carcinogenic esters) in croton oil.
- A tetracyclic alcohol; chemical formula: C20H28O6.
- This is in striking contrast to phorbol esters, which mimic G q pathway-produced DAG and cause strongly hyperactive locomotion within 1-2 hr of omnidirectional contact.
- Neutrophils stimulated to respiratory burst by phorbol myristate acetate activate IQ, and inhibitor studies have identified myeloperoxidase as the enzyme responsible.
Origin
1930s: from Greek phorbē 'fodder' (from pherbein 'to feed') + -ol.
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