单词	picrotoxin
释义	picrotoxin /ˌpɪkrə(ʊ)ˈtɒksɪn / noun [mass noun] Medicine A bitter compound used to stimulate the respiratory and nervous system, especially in treating barbiturate poisoning. This toxin is obtained from the seeds of the shrub Anamirta cocculus (family Menispermaceae). When the synapses of these inhibitory neurons are blocked by drugs (such as of picrotoxin or penicillin), the excitatory network can sustain a chain reaction leading to an epileptiform discharge.... The only synaptic feedback to the pyloric pacemaker group through the EP to PD inhibitory synapse was removed by applying 10-5 M picrotoxin in the bath. Picrotoxin eliminates frequency selectivity of an auditory interneuron in a bushcricket. Origin Mid 19th century: from Greek pikros 'bitter' + toxin.
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