单词	leukaemogenic
释义	leukaemogenic /luːˌkiːmə(ʊ)ˈdʒɛnɪk / (US leukemogenic) adjective Medicine Relating to or promoting the development of leukaemia.However, caution must be exercised in making such assumptions because many inappropriately expressed genes from the leukemic clone may retain important diagnostic value, but prove not to be leukemogenic.... This phenomenon can best be explained by the discovery that the site of breakage on chromosome 9 occurs at different places, which alters the product of the translocation and thus the leukemogenic mechanism. The most widely accepted and significant leukemogenic mechanism attributed to the fusion protein involves the constitutive stimulation of tyrosine kinase. Derivatives leukaemogen /luːˈkiːmədzən/ noun ... Benzene is a human leukemogen and the metabolites are thought to be deeply involved in benzene leukemogenesis. leukaemogenesis noun ... We speculate that p53 protein overexpression in this bone marrow failure syndrome may represent an early indicator of significant DNA genetic alteration, which is a crucial step in the process of leukemogenesis. Our understanding of the molecular biology of the t translocation has contributed to the current theories of leukemogenesis in CML. This was most intense when he was working on his idea that there is no threshold for radiation-induced leukemogenesis.
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