annoy, irritate, exasperate, anger, irk, vex, put out, nettle, provoke, incense, gall, rile, infuriate, antagonize, get on someone's nerves, rub up the wrong way, make someone's blood boil, ruffle someone's feathers, ruffle, try someone's patience;

offend, pique, peeve, rankle with

informal aggravate, needle, make someone see red, hack off, get someone's back up, get someone's goat, get under someone's skin, get up someone's nose, get in someone's hair, get someone's dander up, bug, get, miff

British informal wind up, get at, nark, get across, get on someone's wick

North American informal tee off, tick off, burn up, rankle, ride, gravel

informal, dated give someone the pip

vulgar slang piss off

rare exacerbate, hump, rasp