1. With desperation
   "'Why can't you understand?,' she asked despairingly"
   - despondently

See also: despairing

• antioxidant
• antiparallel
• antiparticle
• antipasto
• antipathetic
• antipathetical
• antipathy
• antipattern
• antiperistaltic
• antipernicious anemia factor
• antipersonnel
• antiperspirant
• antiphlogistic
• antiphon
• antiphonal
• antiphonary
• antiphony
• antiphrasis
• antipodal
• antipodal opposition
• antipode
• antipodean
• antipodes
• antipollution
• antipope