1. Sufficiently significant to affect the whole world
   - earthshaking, world-shaking, world-shattering

See also: important, significant

• guinea gold vine
• Guinea grains
• guinea hen
• Guinea pepper
• guinea pig
• Guinea worm
• Guinea worm disease
• Guinea-Bissau
• Guinea-Bissau monetary unit
• Guinea-Bissau peso
• guinea-hen flower
• Guinean
• Guinean franc
• Guinean monetary unit
• Guinevere
• Guinness
• guipure
• guiro
• guise
• Guiseppe Fortunino Francesco Verdi
• Guiseppe Guarneri
• guitar
• guitar pick
• guitar player
• guitar-shaped