1. Sufficiently significant to affect the whole world
   - earthshaking, world-shaking, world-shattering

See also: important, significant

• protist
• Protista
• protistan
• Protium
• Protium guianense
• Protium heptaphyllum
• proto
• Proto-Indo European
• Proto-Norse
• proto-oncogene
• protoactinium
• protoanthropology
• protoarchaeology
• protoarcheology
• protoavis
• protoceratops
• protocol
• protoctist
• protoctist family
• protoctist genus
• protoctist order
• Protoctista
• protogeometric
• protoheme
• protohemin