1. That cripples or disables or incapacitates
   - crippling, disabling

1. Make unable to perform a certain action
   - disable, disenable 
2. Injure permanently
   - disable, invalid, handicap

See also: unhealthful

Type of: alter, change, injure, modify, wound

• unpremeditated
• unprepared
• unprepossessing
• unpresentable
• unpresidential
• unpressed
• unpretending
• unpretentious
• unpretentiously
• unpretentiousness
• unpreventable
• unpriestly
• unprincipled
• unprintable
• open-end wrench
• open-ended
• open-eyed
• open-face sandwich
• open-faced
• open-heart surgery
• open-hearth
• open-hearth furnace
• open-hearth process
• open-minded
• open-mindedly