1. Full of sorrow
   - brokenhearted, heartbroken 
2. Without or almost without hope
   "too heartsick to fight back"
   - despondent

See also: heartsickness, hopeless, sorrowful

• shamanise
• shamanism
• shamanist
• shamanistic
• shamanize
• Shamash
• shamble
• shambles
• shambling
• shambolic
• shambolically
• shame
• shame plant
• shamed
• shamefaced
• shamefacedly
• shamefacedness
• shameful
• shamefully
• shamefulness
• shameless
• shamelessly
• shamelessness
• shamisen
• shammer