to make (somebody) (esp a former friend or supporter) hostile or indifferent, esp where attachment formerly existed
to cause (something, e.g. affection) to be withdrawn or diverted
to convey or transfer (e.g. property or a right) to another, usu by a specific act
The grantee of any extensive tract of land generally finds it for his interest to alienate … the greater part of it — Adam Smith
alienator noun
[Latin alienatus, past part. of alienare to estrange, from alienus: see alien1]