somebody or something despised or unacceptable
opinions that are anathema to us
a ban or curse solemnly pronounced by ecclesiastical authority and accompanied by excommunication, or the person or thing that is the object of such a ban or curse
a vigorous denunciation; a curse
Thereupon Dan Cullen sat up on his crazy couch and pronounced anathema upon her and all her breed — Jack London
[via late Latin from Greek anathema thing devoted to evil, curse, from anatithenai to dedicate, from ana- + tithenai to put]