(often + from) to arouse enmity or indifference in (somebody) in place of affection;
Of my country and family I have little to say. Ill usage and length of years have driven me from the one, and estranged me from the other — Poe
Their minds, lately estranged, seemed suddenly to have been drawn closer, one to the other — James Joyce
estranged adj
estrangement noun
[early French estranger from medieval Latin extraneare, from Latin extraneus: see strange]