to cause (something) to fail as a result of too much heat, friction, or electric current

to cause (something) to be no longer active

The disease had burned itself out

to exhaust (somebody) from overwork or stress

He had burned himself out by the age of thirty

said of a fuse or other electrical device: to cease to conduct electricity when the filament has melted

said of a jet or rocket engine: to cease to operate having used up all its fuel

to become exhausted from overwork or stress