Tay-Sachs Diseasenoun [ U ]
uk/teɪˈsæks dɪˌziːz/us/ˈteɪˌsæks dɪˌziːz/abbreviation TD, abbreviation TSD, B variant GM2 gangliosidosis specializeda genetic disease in which the body is unable to get rid of a fatty substance called ganglioside so that it builds up in the brain, causing the nerves to stop working properly and eventually leading to death, usually before the age of three:
For a child to have Tay-Sachs Disease, both parents must have the defective gene responsible.