In still other cases the symptoms resemble those which occur in extreme hyperpyrexia dependent upon overwhelming and paralysis of the nervous centres.

Later, signs of increased intra-cranial tension develop: unconsciousness deepening into coma, paralysis of ocular muscles, rapid pulse, Cheyne-Stokes respiration, and sometimes hyperpyrexia.

The important pathological condition to be combated is the hyperpyrexia, and not the cold stage, as in intermittents.